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CAS No 153259-65-5 , 4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylic
acid

  • Name: 4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylic
    acid
  • Synonyms: S1455_Selleck; Ariflo (TN);Ariflo; 1xlx; SB 207499;4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylic
    acid; SB207499; 1xom; Cilomilast [USAN:INN]; 153259-65-5;
  • CAS Registry Number:
  • Flash Point: 285.9°C
  • Boiling Point: 549.1°Cat760mmHg
  • Density: 1.21g/cm3
  • Refractive index: 1.568
  • Flash Point: 285.9°C
  • Molecular Weight: 343.4168
  • InchiKey: CFBUZOUXXHZCFB-UHFFFAOYSA-N
  • InChI: InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)
    10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)
  • Molecular Formula: C20H25NO4
  • Molecular Structure:CAS No:153259-65-5 4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylic<br />acid

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References of 4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylic
acid
Title: Cilomilast
CAS Registry Number: 153259-65-5
CAS Name: cis-4-Cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexanecarboxylic acid
Manufacturers' Codes: SB-207499
Trademarks: Ariflo (GSK)
Molecular Formula: C20H25NO4
Molecular Weight: 343.42
Percent Composition: C 69.95%, H 7.34%, N 4.08%, O 18.64%
Literature References: Selective phosphodiesterase 4 (PDE4) inhibitor. Prepn: S. B. Christensen, WO 9319749; idem, US 5552438 (1993, 1996 both to SmithKline Beecham); idem et al., J. Med. Chem. 41, 821 (1998). Anti-inflammatory activity: M. S. Barnette et al., J. Pharmacol. Exp. Ther. 284, 420 (1998); D. E. Griswold et al., ibid. 705. Pharmacology and therapeutic potential in asthma and chronic obstructive pulmonary disease (COPD): T. J. Torphy et al., Pulm. Pharmacol. Ther. 12, 131-135 (1999). Clinical pharmacokinetics and bioavailability: B. D. Zussman et al., Pharmacotherapy 21, 653 (2001). Clinical trial in COPD: C. H. Compton et al., Lancet 358, 265 (2001). Review of pharmacology and clinical experience: M. A. Giembycz, Expert Opin. Invest. Drugs 10, 1361-1379 (2001).
Properties: White solid, mp 157°.
Melting point: mp 157°
Therap-Cat: Antiasthmatic; in treatment of chronic obstructive pulmonary disease.
Keywords: Antiasthmatic (Nonbronchodilator); Phosphodiesterase Inhibitor.