CAS No 61-00-7 , Ethanone,1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-

Name: Ethanone,1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-
Synonyms: Plivafen; 3-Acetyl-10-(3-dimethylaminopropyl)phenothiazine;Ethanone,1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-;10-(3-Dimethylaminopropyl)phenothiazin-3-yl methyl ketone; Azepromazine;2-Acetylpromazine; Acetopromazine; Acepromazine; Placivet;Ketone,10-[3-(dimethylamino)propyl]phenothiazin-2-yl methyl (8CI); Acetacin;Acetylpromazine; Plegicil; Acetazin; CC 64; 1522CB;Acepromazin; Vetranquil; Acetazine;
CAS Registry Number:61-00-7
Safety Statements: Poison by ingestion, intravenous, and subcutaneous routes. A flammable liquid. When heated to decomposition it emits toxic fumes of SOx and NOx. See also KETONES. An animal tranquilizer.
EINECS: 200-496-0
Molecular Weight: 326.49
InChI: InChI=1/C19H22N2OS/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19/h4-5,7-10,13H,6,11-12H2,1-3H3
Molecular Formula: C19H22 N2 O S
Molecular Structure:

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References of Ethanone,1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-

Title: Acepromazine
CAS Registry Number: 61-00-7
CAS Name: 1-[10-[3-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]ethanone
Synonyms: 10-[3-(dimethylamino)propyl]phenothiazin-2-yl methyl ketone; 2-acetyl-10-(3-dimethylaminopropyl)phenothiazine; 3-acetyl-10-(3-dimethylaminopropyl)phenothiazine; 10-(3-dimethylaminopropyl)phenothiazine-3-ethylone; acetazine; acetopromazine; acetylpromazine
Manufacturers' Codes: 1522-CB
Molecular Formula: C19H22N2OS
Molecular Weight: 326.46
Percent Composition: C 69.90%, H 6.79%, N 8.58%, O 4.90%, S 9.82%
Literature References: Prepn: J. Schmitt et al., Bull. Soc. Chim. Fr. 1957, 938. Pharmacology and toxicology: W. Wirth et al., Arch. Int. Pharmacodyn. 123, 78 (1959). GLC determn in plasma: S. Ballard, T. Tobin, J. Toxicol. Environ. Health 7, 745 (1981). Clinical trial in cats: D. H. Dyson et al., Can. Vet. J. 33, 462 (1992); in horses: A. Hashem, H. Keller, J. Vet. Pharmacol. Ther. 16, 359 (1993). Brief review of clinical experience: N. Brock, Can. Vet. J. 35, 458-459 (1994).
Properties: Yellow-colored oil, bp0.5 220-240°.
Boiling point: bp0.5 220-240°

Derivative Type: Maleate
CAS Registry Number: 3598-37-6
Trademarks: Atravet (Wyeth-Ayerst); Calmivet (Stricker); Plegicil (Sanofi); PromAce (Fort Dodge); Sedalin (Chassot); Vetranquil (Sanofi)
Molecular Formula: C19H22N2OS.C4H4O4
Molecular Weight: 442.53
Percent Composition: C 62.42%, H 5.92%, N 6.33%, O 18.08%, S 7.25%
Properties: Yellow crystals from ethyl acetate, mp 135-136°. pKa 9.3. Sol in water, alcohol, chloroform. pH of aq solns: ~4.0. LD50 orally in rats: 400 mg/kg; i.v. in mice: 59 mg/kg (Wirth).
Melting point: mp 135-136°
pKa: pKa 9.3
Toxicity data: LD50 orally in rats: 400 mg/kg; i.v. in mice: 59 mg/kg (Wirth)

Therap-Cat-Vet: Tranquilizer.