Home > Name List By 2 > 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine

CAS No 58-38-8 , 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine

  • Name: 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
  • Synonyms: Procloperazine; Chlormeprazine;2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine; Tementil; Prochlorperazin; Prochlorpromazine; Stemetil;Compazine; Chlorperazine; Capazine;
  • CAS Registry Number:
  • Melting Point: 228 ºC
  • Flash Point: 271.2°C
  • Boiling Point: 524.8°Cat760mmHg
  • Density: 1.217g/cm3
  • Safety Statements: Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: headache, blood pressure elevation. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl−.
  • Flash Point: 271.2°C
  • EINECS: 200-379-4
  • Molecular Weight: 373.94266
  • InchiKey: WIKYUJGCLQQFNW-UHFFFAOYSA-N
  • InChI: InChI=1S/C20H24ClN3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)
    25-20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3
  • Molecular Formula: C20H24ClN3S
  • Molecular Structure:CAS No:58-38-8 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine

Related products

Search by region :

Select to

58-38-8 10H-Phenothiazine,2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-

Contact Supplier

58-38-8 Prochlorperazine

Contact Supplier

58-38-8 Prochlorperazine

  • United States CBSCHEM LIMITED null
  • Fax: (888) 557-9843
  • Address: 621 South 48th Street, Suite 115,Tempe, AZ 85281 null,nullUnited States
Contact Supplier

58-38-8 PROCHLORPERAZINE-D3

  • United States EJY Tech, Inc. [Manufacturer]
  • Tel: 301-526-7059
  • Fax: 301-561-6521
  • Address: 9430 Key West Avenue
    Suite 220
    Rockville , MD 20850 null,nullUnited States
Contact Supplier

58-38-8 PROCHLORPERAZINE MALEATE

  • Canada Synth?se AptoChem Inc. [Manufacturer]
  • Tel: 514-496-4252
  • Fax: 514-496-4253
  • Address: Synth?se AptoChem Inc.
    6100 Royalmount Ave
    Montreal, QC
    Canada
    H4P 2R2 null,nullCanada
Contact Supplier

58-38-8 10H-Phenothiazine,2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-

Contact Supplier

58-38-8 PROCHLORPERAZINE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
Contact Supplier

Select to

1/1
References of 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
Title: Prochlorperazine
CAS Registry Number: 58-38-8
CAS Name: 2-Chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine
Synonyms: 3-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine; 2-chloro-10-[3-(1-methyl-4-piperazinyl)propyl]phenothiazine; N-[g-(4￠-methylpiperazinyl-1￠)propyl]-3-chlorophenothiazine; chlormeprazine; prochlorpemazine; proclorperazine
Manufacturers' Codes: Bayer A 173; RP-6140; SKF-4657
Molecular Formula: C20H24ClN3S
Molecular Weight: 373.94
Percent Composition: C 64.24%, H 6.47%, Cl 9.48%, N 11.24%, S 8.57%
Literature References: Prepn: R. J. Horclois, GB 780193; FR 1167627; US 2902484 (1957, 1958, 1959 all to Rh?ne-Poulenc). Pharmacology and toxicity: S. Courvoisier et al., C.R. Seances Soc. Biol. Ses Fil. 152, 1371 (1958). Pharmacokinetics: W. B. Taylor, D. N. Bateman, Br. J. Clin. Pharmacol. 23, 137 (1987). Clinical efficacy as antiemetic and antipsychotic: J. Lapierre et al., Can. Psychiatr. Assoc. J. 14, 267 (1969). Clinical trial in treatment of nausea, dizziness and vertigo: A. E. Ward, Br. J. Clin. Pract. 42, 228 (1988).
 
Derivative Type: Dimaleate
CAS Registry Number: 84-02-6
Trademarks: Buccastem (Reckitt Benckiser); Compazine (GSK); Meterazine; Stemetil (Aventis); Vertigon (GSK)
Molecular Formula: C20H24ClN3S.2C4H4O4
Molecular Weight: 606.09
Percent Composition: C 55.49%, H 5.32%, Cl 5.85%, N 6.93%, S 5.29%, O 21.12%
Properties: Minute crystals, mp 228°. Very slightly sol in water (<0.1% at 20°). Slightly sol in methanol, ethanol. Practically insol in ether, benzene, chloroform. LD50 in mice (mg/kg): 400 s.c.; 120 i.p.; 90 i.v., 400 orally (Courvoisier).
Melting point: mp 228°
Toxicity data: LD50 in mice (mg/kg): 400 s.c.; 120 i.p.; 90 i.v., 400 orally (Courvoisier)
 
Derivative Type: Dimethanesulfonate
CAS Registry Number: 51888-09-6
Synonyms: Prochlorperazine mesylate
Trademarks: Novamin (Shionogi); Tementil (Aventis)
Molecular Formula: C20H24ClN3S.2CH4O3S
Molecular Weight: 566.15
Percent Composition: C 46.67%, H 5.70%, Cl 6.26%, N 7.42%, S 16.99%, O 16.96%
 
Therap-Cat: Antiemetic; antipsychotic. In treatment of vertigo.
Therap-Cat-Vet: Antiemetic.
Keywords: Antiemetic; Antipsychotic; Phenothiazines.