Home > Name List By other > (7S,9S)-9-acetyl-7-[(2R,4S,5S, 6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8, 10-dihydro-7H-tetracene-5,12-...

CAS No 58957-92-9 , (7S,9S)-9-acetyl-7-[(2R,4S,5S,
6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,
10-dihydro-7H-tetracene-5,12-dione

  • Name: (7S,9S)-9-acetyl-7-[(2R,4S,5S,
    6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,
    10-dihydro-7H-tetracene-5,12-dione
  • Synonyms: idarubicin hydrochloride; Idarubicine [INN-French];(7S,9S)-9-acetyl-7-[(2R,4S,5S,
    6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,
    10-dihydro-7H-tetracene-5,12-dione;Idamycin; Idarubicina [INN-Spanish]; Idarubicinum [INN-Latin]; Idarubicina;
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 2
  • Density: 1.565 g/cm3
  • Safety Statements: S53;S45;
  • Hazard Symbols: T+
  • Molecular Weight: 497.49388
  • InchiKey: XDXDZDZNSLXDNA-TZNDIEGXSA-N
  • InChI: InChI=1S/C26H27NO9/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,
    11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31/
    h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3/t10-,15-,16-,17-,21+,26-/m0/s1
  • Risk Statements: 60-61-28-40
  • Molecular Formula: C26H27NO9
  • Molecular Structure:CAS No:58957-92-9 (7S,9S)-9-acetyl-7-[(2R,4S,5S,<br />6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,<br />10-dihydro-7H-tetracene-5,12-dione

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58957-92-9 IDARUBICIN

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
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58957-92-9 Idarubicin

  • Company has built a high standard R&D center which equipped first-class research instruments. The center includes synthesis laboratory, analytical laboratory, applied research laboratory. We also gathered a group of technical talents who were from ho...
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58957-92-9 Idarubicin

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
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58957-92-9 Idarubicin

  • China Boronsyn Co.,Ltd [Manufacturer]
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58957-92-9 Idarubicin

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58957-92-9 Idarubicin

  • China Kouting Chemical Co.,Ltd [Importer/Exporter]
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58957-92-9 Idarubicin

58957-92-9 IDARUBICIN

  • China HANGZHOU THINK CHEMICAL CO. [Manufacturer]
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References of (7S,9S)-9-acetyl-7-[(2R,4S,5S,
6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,
10-dihydro-7H-tetracene-5,12-dione
Title: Idarubicin
CAS Registry Number: 58957-92-9
CAS Name: (7S,9S)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione
Synonyms: (1S,3S)-3-acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside; 4-demethoxydaunomycin; 4-demethoxydaunorubicin; DMDR
Manufacturers' Codes: IMI-30; NSC-256439
Molecular Formula: C26H27NO9
Molecular Weight: 497.49
Percent Composition: C 62.77%, H 5.47%, N 2.82%, O 28.94%
Literature References: Orally active anthracycline; analog of daunorubicin, q.v. Prepn: B. Patelli et al. DE 2525633; eidem, US 4046878 (1976, 1977 both to Soc. Farmac. Ital.); and antitumor activity: F. Arcamone et al., Cancer Treat. Rep. 60, 829 (1976). Total synthesis for larger scale preparation: M. J. Broadhurst et al., Chem. Commun. 1982, 158. Synthesis of optically pure isomers: Y. Kimura et al., Bull. Chem. Soc. Jpn. 59, 423 (1986). Metabolism and biodistribution in rats: G. Zini et al., Cancer Chemother. Pharmacol. 16, 107 (1986). HPLC determn in plasma: S. S. N. De Graaf et al., J. Chromatogr. 491, 501 (1989). Clinical pharmacokinetics: H. C. Gillies et al., Br. J. Clin. Pharmacol. 23, 303 (1987). Clinical evaluation of cardiac toxicity: F. Villani et al., Eur. J. Cancer Clin. Oncol. 25, 13 (1989). Reviews of pharmacology and antitumor efficacy: A. M. Casazza, Cancer Treat. Rep. 63, 835-844 (1979); F. Ganzina et al., Invest. New Drugs 4, 85-105 (1986). Symposium on clinical experience in acute leukemias: Semin. Oncol. 17, Suppl. 2, 1-36 (1989).
 
Derivative Type: Hydrochloride
CAS Registry Number: 57852-57-0
Trademarks: Idamycin (Pharmacia & Upjohn); Zavedos (Pharmacia & Upjohn)
Molecular Formula: C26H27NO9.HCl
Molecular Weight: 533.95
Percent Composition: C 58.48%, H 5.29%, N 2.62%, O 26.97%, Cl 6.64%
Properties: Orange crystalline powder, mp 183-185° (Arcamone); also reported as mp 172-174° (Broadhurst). [a]D20 +205° (c = 0.1 in methanol) (Arcamone); also reported as [a]D20 +188° (c = 0.10 in methanol) (Kimura).
Melting point: mp 183-185° (Arcamone); mp 172-174° (Broadhurst)
Optical Rotation: [a]D20 +205° (c = 0.1 in methanol) (Arcamone); [a]D20 +188° (c = 0.10 in methanol) (Kimura)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antibiotics and Analogs; Anthracyclines; Topoisomerase II Inhibitor.