Home > Name List By e > Eburnamenine-14-carboxylicacid, 11-bromo-14,15-dihydro-14-hydroxy-, methyl ester, (3a,14b,16a)-

CAS No 57475-17-9 , Eburnamenine-14-carboxylicacid, 11-bromo-14,15-dihydro-14-hydroxy-, methyl ester, (3a,14b,16a)-

  • Name: Eburnamenine-14-carboxylicacid, 11-bromo-14,15-dihydro-14-hydroxy-, methyl ester, (3a,14b,16a)-
  • Synonyms: Brovincamine; Brovincamina [INN-Spanish]; cis-11-bromovincamine; Brovincamine (INN); Brovincaminum [INN-Latin];Eburnamenine-14-carboxylicacid, 11-bromo-14,15-dihydro-14-hydroxy-, methyl ester, (3a,14b,16a)-; 9-Bromvincamin;
  • CAS Registry Number:
  • Flash Point: 285.2°C
  • Boiling Point: 547.9°Cat760mmHg
  • Density: 1.59g/cm3
  • Refractive index: 1.705
  • Flash Point: 285.2°C
  • Molecular Weight: 433.3388
  • InchiKey: WYIJGAVIVKPUGJ-GIVPXCGWSA-N
  • InChI: InChI=1S/C21H25BrN2O3/c1-3-20-8-4-9-23-10-7-15-14-6-5-13(22)11-16(14)24
    (17(15)18(20)23)21(26,12-20)19(25)27-2/h5-6,11,18,26H,3-4,7-10,12H2,
    1-2H3/t18-,20+,21+/m1/s1
  • Molecular Formula: C21H25BrN2O3
  • Molecular Structure:CAS No:57475-17-9 Eburnamenine-14-carboxylicacid, 11-bromo-14,15-dihydro-14-hydroxy-, methyl ester, (3a,14b,16a)-

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References of Eburnamenine-14-carboxylicacid, 11-bromo-14,15-dihydro-14-hydroxy-, methyl ester, (3a,14b,16a)-
Title: Brovincamine
CAS Registry Number: 57475-17-9
CAS Name: (3a,14b,16a)-11-Bromo-14,15-dihydro-14-hydroxyeburnamenine-14-carboxylic acid methyl ester
Synonyms: cis-11-bromovincamine
Molecular Formula: C21H25BrN2O3
Molecular Weight: 433.34
Percent Composition: C 58.20%, H 5.81%, Br 18.44%, N 6.46%, O 11.08%
Literature References: Cerebrovascular agent, vincamine deriv. Prepn: P. Pfaeffli, DE 2458164; idem, US 4146643 (1975, 1979 both to Sandoz). HPLC determn in plasma: R. R. Brodie, L. F. Chasseaud, J. Chromatogr. 228, 413 (1982). Effect on autonomic nervous system in laboratory animals: K. Kushiku et al., J. Pharmacobio-Dyn. 7, 177 (1984). Cardiovascular effects, mechanistic studies: eidem, Clin. Exp. Pharmacol. Physiol. 12, 121 (1985). Mode of action studies: T. Katsuragi et al., Gen. Pharmacol. 15, 43 (1984). Clinical trials in patients with multi-infarct dementia: S. Hagstadius et al., Psychopharmacology 83, 321 (1984).
Properties: Crystals from isopropanol, mp 214° (dec). [a]D20 +8.7° (1% in CHCl3).
Melting point: mp 214° (dec)
Optical Rotation: [a]D20 +8.7° (1% in CHCl3)
 
Derivative Type: Hydrogen fumarate
CAS Registry Number: 84964-12-5
Manufacturers' Codes: BV-26-723
Trademarks: Sabromin (Sandoz); Zabromin (Sandoz)
Molecular Formula: C21H25BrN2O3.C4H4O4
Molecular Weight: 549.41
Percent Composition: C 54.65%, H 5.32%, Br 14.54%, N 5.10%, O 20.38%
Properties: mp 144°. [a]D20 +4.7° (0.388% in H2O).
Melting point: mp 144°
Optical Rotation: [a]D20 +4.7° (0.388% in H2O)
 
Therap-Cat: Vasodilator (peripheral).
Keywords: Vasodilator (Peripheral).