Title: Irsogladine
CAS Registry Number: 57381-26-7
CAS Name: 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine
Synonyms: 2,4-diamino-6-(2,5-dichlorophenyl)-
s-triazine; dicloguamine
Molecular Formula: C9H7Cl2N5
Molecular Weight: 256.09
Percent Composition: C 42.21%, H 2.76%, Cl 27.69%, N 27.35%
Literature References: Gastric cytoprotectant with benzoguanamine skeleton. Prepn: H. Murai
et al., DE 2506814;
eidem, US 3966728 (1975, 1976 both to Nippon Shinyaku). Series of articles on pharmacology: F. Ueda
et al., Arzneim.-Forsch. 34, 474-491 (1984). Tissue distribution studies: T. Ando
et al., ibid. 36, 1221 (1984). Metabolism: M. Sugiyama
et al., ibid. 1229. Phase I study: M. Nakashima
et al., ibid. 34, 492 (1984). Mechanism of antiulcer action study: F. Ueda
et al., Oyo Yakuri 33, 157 (1987),
C.A. 107, 17604a (1987).
Properties: Colorless crystals from dioxane, mp 268-269°.
Melting point: mp 268-269°
Derivative Type: Maleate
CAS Registry Number: 84504-69-8
Manufacturers' Codes: MN-1695
Trademarks: Gaslon (Nippon Shinyaku)
Molecular Formula: C9H7Cl2N5.C4H4O4
Molecular Weight: 372.16
Percent Composition: C 41.95%, H 2.98%, Cl 19.05%, N 18.82%, O 17.20%
Properties: Crystals from dioxane, mp 205° (dec). LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474).
Melting point: mp 205° (dec)
Toxicity data: LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474)
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative; Cytoprotectant (Gastric).
