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CAS No 57381-26-7 , 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine Search by region : Canada

  • Name: 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine
  • Synonyms: Irsogladinum [Latin]; Irsogladina [Spanish]; Irsogladine (INN);57381-26-7; Irsogladine [INN];6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine;
  • CAS Registry Number:
  • Melting Point: 268-269 ºC
  • Density: 1.572
  • Refractive index: 1.706
  • Molecular Weight: 256.09138
  • InchiKey: ATCGGEJZONJOCL-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H7Cl2N5/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7/h1-3H,
    (H4,12,13,14,15,16)
  • Molecular Formula: C9H7Cl2N5
  • Molecular Structure:CAS No:57381-26-7 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine

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57381-26-7 IRSOGLADINE

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References of 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine
Title: Irsogladine
CAS Registry Number: 57381-26-7
CAS Name: 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine
Synonyms: 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine; dicloguamine
Molecular Formula: C9H7Cl2N5
Molecular Weight: 256.09
Percent Composition: C 42.21%, H 2.76%, Cl 27.69%, N 27.35%
Literature References: Gastric cytoprotectant with benzoguanamine skeleton. Prepn: H. Murai et al., DE 2506814; eidem, US 3966728 (1975, 1976 both to Nippon Shinyaku). Series of articles on pharmacology: F. Ueda et al., Arzneim.-Forsch. 34, 474-491 (1984). Tissue distribution studies: T. Ando et al., ibid. 36, 1221 (1984). Metabolism: M. Sugiyama et al., ibid. 1229. Phase I study: M. Nakashima et al., ibid. 34, 492 (1984). Mechanism of antiulcer action study: F. Ueda et al., Oyo Yakuri 33, 157 (1987), C.A. 107, 17604a (1987).
Properties: Colorless crystals from dioxane, mp 268-269°.
Melting point: mp 268-269°
 
Derivative Type: Maleate
CAS Registry Number: 84504-69-8
Manufacturers' Codes: MN-1695
Trademarks: Gaslon (Nippon Shinyaku)
Molecular Formula: C9H7Cl2N5.C4H4O4
Molecular Weight: 372.16
Percent Composition: C 41.95%, H 2.98%, Cl 19.05%, N 18.82%, O 17.20%
Properties: Crystals from dioxane, mp 205° (dec). LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474).
Melting point: mp 205° (dec)
Toxicity data: LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474)
 
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative; Cytoprotectant (Gastric).