Home > Name List By other > [(2S)-2-[methyl-[2-[methyl-[(2S)-1-(3,4, 5-trimethoxybenzoyl)oxybutan-2-yl]amino]ethyl]amino]butyl] 3,4,5-trimethoxybenzoate

CAS No 55769-65-8 , [(2S)-2-[methyl-[2-[methyl-[(2S)-1-(3,4,
5-trimethoxybenzoyl)oxybutan-2-yl]amino]ethyl]amino]butyl]
3,4,5-trimethoxybenzoate

  • Name: [(2S)-2-[methyl-[2-[methyl-[(2S)-1-(3,4,
    5-trimethoxybenzoyl)oxybutan-2-yl]amino]ethyl]amino]butyl]
    3,4,5-trimethoxybenzoate
  • Synonyms: [(2S)-2-[methyl-[2-[methyl-[(2S)-1-(3,4,
    5-trimethoxybenzoyl)oxybutan-2-yl]amino]ethyl]amino]butyl]
    3,4,5-trimethoxybenzoate; SureCN309587;Butobendine [INN]; UNII-RP2J52327K; 55769-65-8;
  • CAS Registry Number:
  • Flash Point: 333.7°C
  • Boiling Point: 628.1°Cat760mmHg
  • Density: 1.127g/cm3
  • Refractive index: 1.522
  • Flash Point: 333.7°C
  • Molecular Weight: 620.73092
  • InchiKey: ZKSIPEYIAHUPNM-ZEQRLZLVSA-N
  • InChI: InChI=1S/C32H48N2O10/c1-11-23(19-43-31(35)21-15-25(37-5)29(41-9)26(16-
    21)38-6)33(3)13-14-34(4)24(12-2)20-44-32(36)22-17-27(39-7)30(42-10)28
    (18-22)40-8/h15-18,23-24H,11-14,19-20H2,1-10H3/t23-,24-/m0/s1
  • Molecular Formula: C32H48N2O10
  • Molecular Structure:CAS No:55769-65-8 [(2S)-2-[methyl-[2-[methyl-[(2S)-1-(3,4,<br />5-trimethoxybenzoyl)oxybutan-2-yl]amino]ethyl]amino]butyl]<br />3,4,5-trimethoxybenzoate

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55769-65-8 BUTOBENDINE

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55769-65-8 Butobendine

  • Butobendine, 99%
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55769-65-8 Butobendine

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55769-65-8 BUTOBENDINE

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References of [(2S)-2-[methyl-[2-[methyl-[(2S)-1-(3,4,
5-trimethoxybenzoyl)oxybutan-2-yl]amino]ethyl]amino]butyl]
3,4,5-trimethoxybenzoate
Title: Butobendine
CAS Registry Number: 55769-65-8
CAS Name: 3,4,5-Trimethoxybenzoic acid 1,2-ethanediylbis[(methylimino)[(2S)-2-ethyl-2,1-ethanediyl]] ester
Synonyms: (2S,2￠S)-N,N￠-dimethyl-N,N￠-bis-1-(3￠,4￠,5￠-trimethoxybenzoyloxy)butyl-2-ethylenediamine; (+)-(S,S)-ethylenebis[(methylimino)(2-ethylethylene)]bis(3,4,5-trimethoxybenzoate)
Molecular Formula: C32H48N2O10
Molecular Weight: 620.73
Percent Composition: C 61.92%, H 7.79%, N 4.51%, O 25.78%
Literature References: Antiarrhythmic agent which increases cardiac blood flow. Prepn: M. Eckstein et al., DE 2435380; eidem, US 4021473 (1975, 1977 both to Polfa). Series of articles on pharmacology, pharmacokinetics, toxicology: Pol. J. Pharmacol. Pharm. 32, 817-953 (1980). Physical properties: L. Krowczynski et al., ibid. 909. Toxicity data: J. Maj et al., ibid. 823.
Properties: Crystals, mp 60-62°. Also reported as mp 64-65° (Krowczynski). [a]D20 +2.4° (c = 5 in ethanol). Partition coefficient (n-octanol/water) at 20°: 31.49.
Melting point: mp 60-62°; mp 64-65° (Krowczynski)
Optical Rotation: [a]D20 +2.4° (c = 5 in ethanol)
Log P: Partition coefficient (n-octanol/water) at 20°: 31.49
 
Derivative Type: Dihydrochloride
CAS Registry Number: 55769-64-7
Manufacturers' Codes: M-71
Trademarks: Craviten (Polfa)
Molecular Formula: C32H48N2O10.2HCl
Molecular Weight: 693.65
Percent Composition: C 55.41%, H 7.27%, N 4.04%, O 23.07%, Cl 10.22%
Properties: White crystalline powder. Forms mono-, di- and trihydrates, melting range 83-113°. Also reported as crystals from isopropanol, mp 81-83° (Krowczynski). [a]D20 -6.4° (c = 2.5 in ethanol). [a]D20 -7.5° (c = 5 in H2O). [a]D20 -5.5° (c = 5 in pyridine). pH (8% aq soln): 2.20. Partition coefficient (n-octanol/water) at 20°: 4.49. Sol in water, chloroform, ethanol. Slightly sol in methanol. Practically insol in benzene, CCl4, ether. LD50 in rats (mg/kg): 142.0 i.p., 15.8 i.v.; in mice (mg/kg): 550.0 i.p.; in rabbits (mg/kg): 5.1 i.v. (Maj).
Melting point: mp 81-83° (Krowczynski)
Optical Rotation: [a]D20 -6.4° (c = 2.5 in ethanol); [a]D20 -7.5° (c = 5 in H2O); [a]D20 -5.5° (c = 5 in pyridine)
Log P: Partition coefficient (n-octanol/water) at 20°: 4.49
Toxicity data: LD50 in rats (mg/kg): 142.0 i.p., 15.8 i.v.; in mice (mg/kg): 550.0 i.p.; in rabbits (mg/kg): 5.1 i.v. (Maj)
 
Therap-Cat: Antiarrhythmic.
Keywords: Antiarrhythmic.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.