Home > Name List By 4 > 4-[(3, 4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic acid

CAS No 107097-80-3 , 4-[(3,
4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic
acid

  • Name: 4-[(3,
    4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic
    acid
  • Synonyms: CR-1505; Loxiglumidum [Latin]; CR 1505; 107097-80-3; Loxiglumida [Spanish];4-[(3,
    4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic
    acid;Loxizin;
  • CAS Registry Number:
  • Flash Point: 336.1°C
  • Boiling Point: 632.2°Cat760mmHg
  • Density: 1.233g/cm3
  • Refractive index: 1.537
  • Safety Statements: A poison by intravenous. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic vapors of NOx and Cl−.
  • Hazard Symbols: Moderately toxic by ingestion.
  • Flash Point: 336.1°C
  • Molecular Weight: 461.3793
  • InchiKey: QNQZBKQEIFTHFZ-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H30Cl2N2O5/c1-3-4-5-11-25(12-6-13-30-2)21(29)18(9-10-19(26)
    27)24-20(28)15-7-8-16(22)17(23)14-15/h7-8,14,18H,3-6,9-13H2,1-2H3,(H,24,
    28)(H,26,27)
  • Molecular Formula: C21H30Cl2N2O5
  • Molecular Structure:CAS No:107097-80-3 4-[(3,<br />4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic<br />acid

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References of 4-[(3,
4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic
acid
Title: Loxiglumide
CAS Registry Number: 107097-80-3
CAS Name: 4-[(3,4-Dichlorobenzoyl)amino]-5-[(3-methoxypropyl)pentylamino]-5-oxopentanoic acid
Synonyms: (±)-4-(3,4-dichlorobenzamido)-N-(3-methoxypropyl)-N-pentylglutaramic acid
Manufacturers' Codes: CR-1505
Molecular Formula: C21H30Cl2N2O5
Molecular Weight: 461.38
Percent Composition: C 54.67%, H 6.55%, Cl 15.37%, N 6.07%, O 17.34%
Literature References: Cholecystokinin type-1 (CCK-1) antagonist. Prepn: F. Makovec et al., WO 8703869; eidem, US 4769389 (1987, 1988 both to Rotta). Pharmacology and receptor binding: I. Setnikar et al., Arzneim.-Forsch. 37, 703 (1987). Pharmacokinetics: idem et al., ibid. 38, 716 (1988). Effect on bilio-pancreatic secretion: W. E. Schmidt et al., Digestion 46, Suppl. 2, 232 (1990). Clinical evaluation in irritable bowel syndrome: P. A. Cann et al., Ann. N.Y. Acad. Sci. 713, 449 (1994); in nonulcer dyspepsia: A. S. B. Chua et al. ibid. 451; in pancreatitis: K. Shiratori et al., Pancreas 25, e1 (2002).
Properties: Crystals from acetone, mp 113-115°. pKa ~5. Soly in water: 0.01%.
Melting point: mp 113-115°
pKa: pKa ~5
 
Derivative Type: (R)-Form
CAS Registry Number: 119817-90-2
Synonyms: Dexloxiglumide
Manufacturers' Codes: CR-2017
Literature References: HPLC determn in plasma: R. Brodie et al., J. Chromatogr. B 784, 91 (2003). In vitro biopharmaceutical properties: S. Tolle-Sander et al., J. Pharm. Sci. 92, 1968 (2003). Clinical pharmacokinetics: C. Webber et al., Xenobiotica 33, 625 (2003). Clinical evaluation in irritable bowel syndrome: F. Cremonini et al., Am. J. Gastroenterol. 100, 652 (2005).
Properties: Soly (mg/ml): 33 (pH 3.4), 533 (pH 7.5). pKa 4.48.
pKa: pKa 4.48
 
Therap-Cat: Gastroprokinetic.
Keywords: CCK Antagonist; Gastroprokinetic.