Home > Name List By other > (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4, 6,8-tetraenoic acid

CAS No 55079-83-9 , (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,
6,8-tetraenoic acid

  • Name: (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,
    6,8-tetraenoic acid
  • Synonyms: Acitretina; Neotigason;(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,
    6,8-tetraenoic acid; 55079-83-9; Acitretinum; Acitretine; Etretin; Retinoid etretin; all-trans-Acitretin;Soriatane;
  • CAS Registry Number:
  • Transport: UN 3077
  • Density: 1.051 g/cm3
  • Refractive index: 1.569
  • Safety Statements: R36/38,R61,R50/53,
  • Hazard Symbols: T:Toxic;N:Dangerousfortheenvironment;
  • EINECS: 259-474-4
  • Molecular Weight: 326.42934
  • InchiKey: IHUNBGSDBOWDMA-AQFIFDHZSA-N
  • InChI: InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)
    18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+
  • Risk Statements: S53,S37/39,S45,S60,S61,
  • Molecular Formula: C21H26O3
  • Molecular Structure:CAS No:55079-83-9 (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,<br />6,8-tetraenoic acid

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References of (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,
6,8-tetraenoic acid
Title: Acitretin
CAS Registry Number: 55079-83-9
CAS Name: (2E,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid
Synonyms: etretin
Manufacturers' Codes: Ro-10-1670
Trademarks: Neotigason (Roche); Soriatane (Roche)
Molecular Formula: C21H26O3
Molecular Weight: 326.43
Percent Composition: C 77.27%, H 8.03%, O 14.70%
Literature References: Synthetic retinoid; free acid form and major metabolite of etretinate, q.v. Prepn: W. Bollag et al., DE 2414619; eidem, US 4105681 (1974, 1978 both to Hoffmann-La Roche). Teratogenicity study: A. Kistler, H. Hummler, Arch. Toxicol. 58, 50 (1985). HPLC determn in plasma: N. R. Al-Mallah et al., Anal. Lett. 21, 1603 (1988). Pharmacokinetics in humans: F. G. Larsen et al., Pharmacol. Toxicol. 62, 159 (1988). Clinical evaluation in cutaneous lupus erythematosus: T. Ruzicka et al., Arch. Dermatol. 124, 897 (1988). Review of clinical pharmacology: A. Vahlquist, O. Rollman, Dermatologica 175, Suppl. 1, 20-27 (1987). Review of clinical studies in psoriatic and nonpsoriatic dermatoses: J.-M. Geiger, B. M. Czarnetzki, ibid. 176, 182-190 (1988).
Properties: Crystals from hexane, mp 228-230°. LD50 i.p. in mice (mg/kg): >4000 (1 day), 700 (10 days), 700 (20 days) (Bollag, 1978).
Melting point: mp 228-230°
Toxicity data: LD50 i.p. in mice (mg/kg): >4000 (1 day), 700 (10 days), 700 (20 days) (Bollag, 1978)
Therap-Cat: Antipsoriatic.
Keywords: Antipsoriatic.