Home > Name List By 1 > 1-[(2R,4S, 5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione China

CAS No 54-42-2 , 1-[(2R,4S,
5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione Search by region : China

  • Name: 1-[(2R,4S,
    5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione
  • Synonyms: Iduridin; Herplex; Stoxil; Iododeoxyridine;1-[(2R,4S,
    5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione; IUDR;5-Iodo-2'-deoxyuridine; Joddeoxiuridin; Idoxuridin; Herpid;
  • CAS Registry Number:
  • Melting Point: 155-180 ºC
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 2.14g/cm3
  • Refractive index: 30 ° (C=1, 1mol/L NaOH)
  • Alpha: 280 º (C=1,1M NAOH)
  • Water Solubility: 1.6 G/L (20 ºC)
  • Safety Statements: R45;R46;R61
  • Hazard Symbols: T: Toxic;
  • Flash Point: °C
  • EINECS: 200-207-8
  • Molecular Weight: 354.09851
  • InchiKey: XQFRJNBWHJMXHO-RRKCRQDMSA-N
  • InChI: InChI=1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,
    5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
  • Risk Statements: S53;S45
  • Molecular Formula: C9H11IN2O5
  • Molecular Structure:CAS No:54-42-2 1-[(2R,4S,<br />5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione

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54-42-2 1-[(2R,4S, 5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione

  • CBNumber: CB7482614 Chemical Name: (+)-5-Iodo-2'-deoxyuridine Molecular Formula: C9H11IN2O5 Formula Weight: 354.1 CAS No.: 54-42-2 MOL File: Mol file
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References of 1-[(2R,4S,
5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione
Title: Idoxuridine
CAS Registry Number: 54-42-2
CAS Name: 2￠-Deoxy-5-iodouridine
Synonyms: 1-(2-deoxy-b-D-ribofuranosyl)-5-iodouracil; 5-iodo-2￠-deoxyuridine; IdU; IdUR; IUdR; IdUrd
Trademarks: Dendrid (Alcon); Emanil; Herpes-Gel (Master); Herplex (Allergan); Idexur; Idoxene (Spodefell); Idulea; Iduridin (Ferring); Kerecid; Ophthalmadine (SAS); Stoxil (SK & F); Virudox (Bioglan)
Molecular Formula: C9H11IN2O5
Molecular Weight: 354.10
Percent Composition: C 30.53%, H 3.13%, I 35.84%, N 7.91%, O 22.59%
Literature References: Cytotoxic nucleoside with antiviral and antineoplastic activity. Prepn: Prusoff, Biochim. Biophys. Acta 32, 295 (1959); Cheong et al., J. Biol. Chem. 235, 1441 (1960); Chang, Welch, J. Med. Chem. 6, 428 (1963); Amiard, Torelli, FR 1336866 (1963 to Roussel-UCLAF), C.A. 60, 3082g (1964); GB 1024156; Prystas, Sorm, Collect. Czech. Chem. Commun. 29, 121 (1964). Crystal and molecular structure: Camerman, Trotter, Acta Crystallogr. 18, 203 (1965). Review: W. H. Prusoff et al. in Antibiotics vol. 5 (pt. 2), F. E. Hahn, Ed. (Springer-Verlag, New York, 1979) pp 236-261.
Properties: Crystals from water, triclinic, dec 160° (Prusoff; Chang, Welch), 190-195° (Cheong et al.), 240° (Amiard, Torelli), over 175° (Prystas, Sorm). uv max (water): 288 nm (log e 3.87). [a]D25 +7.4° (c = 0.108 in water); [a]D20 +29° (N soda). Physical properties: Ravin, Gulesich, J. Am. Pharm. Assoc. [NS] 4, 122 (1964). pKa 8.25. pH of 0.1% aq soln, about 6. Soly at 25° in mg/ml: 2.0 in water; 2.0 in 0.2N HCl; 74.0 in 0.2N NaOH; 4.4 in methanol; 2.6 in alc; 0.014 in ether; 0.003 in chloroform; 1.6 in acetone; 1.8 in ethyl acetate; 5.7 in dioxane. LD50 i.p. in mice: 2.5 g/kg (Prusoff, 1979).
pKa: pKa 8.25
Optical Rotation: [a]D25 +7.4° (c = 0.108 in water); [a]D20 +29° (N soda)
Absorption maximum: uv max (water): 288 nm (log e 3.87)
Toxicity data: LD50 i.p. in mice: 2.5 g/kg (Prusoff, 1979)
 
Derivative Type: a-Anomer
Synonyms: 1-(2-Deoxy-a-D-erythro-pentofuranosyl)-5-iodouracil; 1-(2-deoxy-a-D-ribofuranosyl)-5-iodouracil; a-2￠-deoxy-5-iodouridine
Properties: Crystals from water, dec 170°. [a]D25 +21.8° (c = 0.170). uv max (water): 288 nm (log e 3.88).
Optical Rotation: [a]D25 +21.8° (c = 0.170)
Absorption maximum: uv max (water): 288 nm (log e 3.88)
 
Therap-Cat: Antiviral.
Keywords: Antiviral; Purines/Pyrimidinones.