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CAS No 53716-49-7 , 2-(6-chloro-9H-carbazol-2-yl)propanoic acid Search by region : China

  • Name: 2-(6-chloro-9H-carbazol-2-yl)propanoic acid
  • Synonyms: Rimadyl; Carprofenum; Imadyl;2-(6-chloro-9H-carbazol-2-yl)propanoic acid; 53716-49-7; Carprofene [INN-French]; Ridamyl; Carprofeno [INN-Spanish]; Carprofenum [INN-Latin];
  • CAS Registry Number:
  • Transport: UN 2811
  • Density: 1.42 g/cm3
  • Refractive index: 1.731
  • Water Solubility: 50mg/ml solution in ethanol gives a clear solution.
  • Safety Statements: R25
  • Hazard Symbols: T: Toxic;
  • EINECS: 258-712-4
  • Molecular Weight: 273.71428
  • InchiKey: PUXBGTOOZJQSKH-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H12ClNO2/c1-8(15(18)19)9-2-4-11-12-7-10(16)3-5-13(12)17-14
    (11)6-9/h2-8,17H,1H3,(H,18,19)
  • Risk Statements: S45
  • Molecular Formula: C15H12ClNO2
  • Molecular Structure:CAS No:53716-49-7 2-(6-chloro-9H-carbazol-2-yl)propanoic acid

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References of 2-(6-chloro-9H-carbazol-2-yl)propanoic acid
Title: Carprofen
CAS Registry Number: 53716-49-7
CAS Name: 6-Chloro-a-methyl-9H-carbazole-2-acetic acid
Manufacturers' Codes: C-5720; Ro-20-5720/000
Trademarks: Imadyl (Roche); Rimadyl (Pfizer)
Molecular Formula: C15H12ClNO2
Molecular Weight: 273.71
Percent Composition: C 65.82%, H 4.42%, Cl 12.95%, N 5.12%, O 11.69%
Literature References: Prepn: L. Berger, A. J. Corraz, DE 2337340; eidem, US 3896145 (1974, 1975 both to Hoffmann-La Roche). Pharmacology: L. O. Randall, H. Baruth, Arch. Int. Pharmacodyn. 220, 94 (1976). Stereospecific assay and disposition: J. M. Kemmerer et al., J. Pharm. Sci. 68, 1274 (1979). Metabolism: F. Rubio et al., ibid. 69, 1245 (1980). Pharmacokinetic and clinical studies in gout: T. F. Yu, J. Perel, J. Clin. Pharmacol. 20, 347 (1980). Use in treatment of rheumatoid arthritis: S. Jalava, Scand. J. Rheumatol. 1983, Suppl. 48, 5-12. Review of pharmacology and clinical efficacy: W. M. O'Brien, G. F. Bagby, Pharmacotherapy 7, 16 (1987).
Properties: Cryst from chloroform, mp 197-198°. LD50 orally in mice: 400 mg/kg (Berger, Corraz).
Melting point: mp 197-198°
Toxicity data: LD50 orally in mice: 400 mg/kg (Berger, Corraz)
Therap-Cat: Anti-inflammatory.
Therap-Cat-Vet: Anti-inflammatory.
Keywords: Antigout; Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives.