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CAS No 525-66-6 , 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol

  • Name: 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
  • Synonyms: Propanolol; Propanix; beta-Propranolol; Betalong; Propanalol; Proprasylyt; Dociton; Inderal; Euprovasin;1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol;
  • CAS Registry Number:
  • Melting Point: 163-164 ºC
  • Density: 1.093 g/cm3
  • Water Solubility: Sol of 1 in 20 of water or alcohol; sltly sol in chloroform; practically insol in ether.
  • Safety Statements: A deadly human poison by ingestion and intravenous routes. Poison experimentally by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by ingestion: cardiac arrhythmias, hallucinations, hypoglycemia, convulsions, and thyroid malfunction. Human reproductive and teratogenic effects by ingestion: extra embryonic structures, abnormal Apgar score in newborn, and abnormal growth statistics. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also INDERAL HYDROCHLORIDE.
  • Hazard Symbols: Highly toxic.
  • EINECS: 208-378-0
  • Molecular Weight: 259.34344
  • InchiKey: AQHHHDLHHXJYJD-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)
    16/h3-9,12,14,17-18H,10-11H2,1-2H3
  • Molecular Formula: C16H21NO2
  • Molecular Structure:CAS No:525-66-6 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol

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525-66-6 propranolol

  • IUPAC NAME-(RS)-1-(1-methylethylamino)-3-(1-naphthyloxy)propan-2-ol MOLECULAR FORMULA-C16H21NO2 MOLAR MASS-259.34 g/mol Propranolol (INN) is a sympatholytic non-selective beta blocker. Sympatholytics are used to treat hypertension, anxiety and panic.
  • India Swapnroop Drugs & Pharmaceuticals [Manufacturer, Trading Company, Distributor/Wholesaler]
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525-66-6 2-Propanol,1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-

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525-66-6 Propranolol

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525-66-6 Propranolol

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525-66-6 Propranolol

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  • Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800, Ningbo,ZhejiangChina
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525-66-6 PROPRANOLOL D7

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525-66-6 PROPRANOLOL HYDROCHLORIDE

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525-66-6 4-HYDROXY PROPRANOLOL-D5

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References of 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
Title: Propranolol
CAS Registry Number: 525-66-6
CAS Name: 1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol
Synonyms: 1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol
Trademarks: Avlocardyl (AstraZeneca); Euprovasin (Magis)
Molecular Formula: C16H21NO2
Molecular Weight: 259.34
Percent Composition: C 74.10%, H 8.16%, N 5.40%, O 12.34%
Literature References: b-Adrenergic blocker. Prepn: BE 640312 and BE 640313; Crowther, Smith, US 3337628 and US 3520919 (1964, 1964, 1967, 1970 all to I.C.I.). Description of optical isomers: Howe, Shanks, Nature 210, 1336 (1966). Biological studies: Barrett, Cullum, Br. J. Pharmacol. 34, 43 (1968). Metabolism: Bond, Nature 213, 721 (1967). Multi-center clinical trial in myocardial infarction: V. Hansteen et al., Br. Med. J. 284, 155 (1982). Use as migraine prophylactic: S. Diamond, E. Millstein, J. Clin. Pharmacol. 28, 193 (1988); S. Diamond et al., Headache 27, 70 (1987). Toxicity data: M. Martin, P. Linee, Eur. J. Med. Chem. 9, 563 (1974). Review of pharmacokinetics: P. A. Routledge, D. G. Shand, Appl. Pharmacokinet. 1980, 464-485; of pharmacology: J. D. Fitzgerald in Pharmacology of Antihypertensive Drugs, A. Scriabine, Ed. (Raven Press, New York, 1980) pp 195-208. Series of articles on use in hypertension: Drugs 37, Suppl. 2, 42-76 (1989).
Properties: Crystals from cyclohexane, mp 96°.
Melting point: mp 96°
 
Derivative Type: Hydrochloride
CAS Registry Number: 318-98-9
Manufacturers' Codes: AY-64043; ICI-45520; NSC-91523
Trademarks: Angilol (DDSA); Apsolol (APS); Bedranol (Lagap); Beprane (Biotherapie); Berkolol (Berk); Beta-Tablinen (Sanorania); Beta-Timelets (Temmler); Cardinol (CP Protea); Deralin (Alphapharm); Dociton (AstraZeneca); Duranol (Elan); Efektolol (Brenner-Efeka); Elbrol (Pfleger); Frekven (Novo); Inderal (Wyeth); Kemi S (Otsuka); Oposim (Richet); Propabloc (Azupharma); Prophylux (Hennig); Propranur (Henning); Rapynogen (Maruko); Sumial (AstraZeneca); Tesnol (Kowa)
Molecular Formula: C16H21NO2.HCl
Molecular Weight: 295.80
Percent Composition: C 64.97%, H 7.50%, N 4.74%, O 10.82%, Cl 11.99%
Properties: Crystals from n-propanol, mp 163-164°. Sol in water, alc. Practically insol in ether, benzene, ethyl acetate. LD50 in mice (mg/kg): 565 orally; 22 i.v.; 107 i.p. (Martin, Linee).
Melting point: mp 163-164°
Toxicity data: LD50 in mice (mg/kg): 565 orally; 22 i.v.; 107 i.p. (Martin, Linee)
 
Therap-Cat: Antihypertensive; antianginal; antiarrhythmic (class II).
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives.