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CAS No 51-21-8 , 5-fluoro-1H-pyrimidine-2,4-dione

  • Name: 5-fluoro-1H-pyrimidine-2,4-dione
  • Synonyms: 5-Fluorouracil; Carac; Fluoroplex; Adrucil; Fluracil; Efudex; 5-FU; Fluoroblastin; fluorouracil;5-fluoro-1H-pyrimidine-2,4-dione; 51-21-8;
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 3
  • Melting Point: 278-286 ºC
  • Density: 1.53 g/cm3
  • Refractive index: 1.542
  • Water Solubility: 12.2 G/L 20 ºC
  • Safety Statements: R20/21/22
  • Hazard Symbols: Xn: Harmful;
  • HS Code: 29335995
  • EINECS: 200-085-6
  • Molecular Weight: 130.077223
  • InchiKey: GHASVSINZRGABV-UHFFFAOYSA-N
  • InChI: InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
  • Risk Statements: S36/37
  • Molecular Formula: C4H3FN2O2
  • Molecular Structure:CAS No:51-21-8 5-fluoro-1H-pyrimidine-2,4-dione

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References of 5-fluoro-1H-pyrimidine-2,4-dione
Title: Fluorouracil
CAS Registry Number: 51-21-8
CAS Name: 5-Fluoro-2,4(1H,3H)-pyrimidinedione
Synonyms: 2,4-dioxo-5-fluoropyrimidine; 5-FU
Manufacturers' Codes: Ro-2-9757; NSC-19893
Trademarks: Adrucil (Adria); Arumel (SS Pharm.); Efudex (Roche); Efudix (Roche); Fluril; Fluracil; Fluoroplex (Allergan); Fluroblastin (Farmitalia); Fluro Uracil; Timazin (Torii)
Molecular Formula: C4H3FN2O2
Molecular Weight: 130.08
Percent Composition: C 36.93%, H 2.32%, F 14.61%, N 21.54%, O 24.60%
Literature References: Prepn: Duschinsky et al., J. Am. Chem. Soc. 79, 4559 (1957); Heidelberger, Duschinsky, US 2802005 (1957); US 2885396 (1959); Barton et al., J. Org. Chem. 37, 329 (1972); O. Miyashita et al., Chem. Pharm. Bull. 29, 3181 (1981). Pharmacokinetics: W. Sadee, C. G. Wong, Clin. Pharmacokinet. 2, 437 (1977). Site of action: F. Maley, G. F. Maley, FEBS Symp. 57, 21 (1979). Comprehensive description: B. C. Rudy, B. Z. Senkowski, Anal. Profiles Drug Subs. 2, 221-244 (1973); S. M. Bayomi, A. A. Al-Badr, ibid. 18, 599-639 (1989). Review of clinical trials: R. M. Hansen, Cancer Invest. 9, 637-642 (1991).
Properties: Crystals from water or methanol-ether, dec 282-283°. Sublimes (0.1 mm) 190-200°. uv max (0.1N HCl): 265-266 nm (e 7070).
Absorption maximum: uv max (0.1N HCl): 265-266 nm (e 7070)
 
Derivative Type: Sodium salt
Trademarks: Effluderm (Allergan)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antimetabolites; Pyrimidine Analogs.