Home > Name List By other > (11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3, 4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7, 11b-tetrahydro-1H-ben...

CAS No 4914-30-1 , (11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,
4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7,
11b-tetrahydro-1H-benzo[a]quinolizine

  • Name: (11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,
    4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7,
    11b-tetrahydro-1H-benzo[a]quinolizine
  • Synonyms: Mebadin;Dehidroemetina; (-)-2,3-Dehydroemetine;(11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,
    4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7,
    11b-tetrahydro-1H-benzo[a]quinolizine; 2,3-Didehydroemetine; 2-Dehydroemetine; Dehydroemetinum; 2,3-didehydro-; Emetine; BT 436;
  • CAS Registry Number:
  • Flash Point: 319.5°C
  • Boiling Point: 604.7°Cat760mmHg
  • Density: 1.19g/cm3
  • Refractive index: 1.606
  • Flash Point: 319.5°C
  • EINECS: 225-542-7
  • Molecular Weight: 478.62302
  • InchiKey: XXLZPUYGHQWHRN-RPBOFIJWSA-N
  • InChI: InChI=1S/C29H38N2O4/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25
    (31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24/h13-16,
    24-25,30H,6-12,17H2,1-5H3/t24-,25+/m1/s1
  • Molecular Formula: C29H38N2O4
  • Molecular Structure:CAS No:4914-30-1 (11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,<br />4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7,<br />11b-tetrahydro-1H-benzo[a]quinolizine

Related products

Select to

4914-30-1 Dehydroemetine

  • Dehydroemetine, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
Contact Supplier

4914-30-1 Dehydroemetine

  • Dehydroemetine, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,nullChina
Contact Supplier

4914-30-1 Dehydroemetine

  • Dehydroemetine, 99%
  • China Tianjin Pharmacn Science Co., Ltd. [Manufacturer]
  • Tel: 86-22-23359620/ 86-13612042162 (mobile)
  • Fax: 86-22-23359620
  • Address: 1006 Sinochem Building, 707 Lianmeng RD, Shijiazhuang 050061, Hebei, China null,nullChina
Contact Supplier

4914-30-1 Dehydroemetine

  • Dehydroemetine
  • China Hallopharma [Manufacturer]
  • Tel: 0086-23-67030808
  • Fax: 0086-23-67030818
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone,401121 ChongqingCHINA Chongqing,nullChina
Contact Supplier

4914-30-1 DEHYDROEMETINE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
Contact Supplier

Select to

1/1
References of (11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,
4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7,
11b-tetrahydro-1H-benzo[a]quinolizine
Title: Dehydroemetine
CAS Registry Number: 4914-30-1
CAS Name: 2,3-Didehydro-6￠,7￠,10,11-tetramethoxyemetan
Synonyms: 2,3-dehydroemetine; 2-dehydroemetine
Molecular Formula: C29H38N2O4
Molecular Weight: 478.62
Percent Composition: C 72.77%, H 8.00%, N 5.85%, O 13.37%
Literature References: Synthetic analog of emetine, q.v.; the (-)-form is therapeutically active. Synthesis of racemic 2,3-dehydroemetine: Brossi et al., Helv. Chim. Acta 42, 772 (1959). Stereospecific synthesis of (±)-form and (±)-2,3-dehydroisoemetine, the (1￠b)-isomer: Clark et al., J. Chem. Soc. 1962, 2479. Separation of the four possible isomers: Brossi, Burkhardt, Experientia 18, 211 (1962). Absolute configuration and bioactivity of isomers: A. Brossi et al., Helv. Chim. Acta 45, 2219 (1962). Prepn of pure (-)-form: A. Brossi, BE 629898; eidem, US 3311633 (1963, 1967 both to Hoffmann-La Roche); N. Whittaker J. Chem. Soc. C 1969, 94. Antiprotozoal activity in vitro: G. H. Al-Khateeb et al., Chemotherapy (Basel) 23, 267 (1977). Review of use in amebiasis: G. Woolfe, Prog. Drug Res. 8, 12 (1965).
Properties: Crystals from isopropyl ether, mp 94-96°. [a]D -183°.
Melting point: mp 94-96°
Optical Rotation: [a]D -183°
 
Derivative Type: (-)-Form dihydrobromide
Molecular Formula: C29H38N2O4.2HBr
Molecular Weight: 640.45
Percent Composition: C 54.39%, H 6.30%, N 4.37%, O 9.99%, Br 24.95%
Properties: Crystals, mp 243-245°. [a]D -97° (methanol). uv max (alc): 282 nm (e 7300).
Melting point: mp 243-245°
Optical Rotation: [a]D -97° (methanol)
Absorption maximum: uv max (alc): 282 nm (e 7300)
 
Derivative Type: (+)-Form dihydrobromide
Properties: Crystals, mp 241-243°. [a]D +95° (methanol). uv max (alc): 282 nm (e 7350).
Melting point: mp 241-243°
Optical Rotation: [a]D +95° (methanol)
Absorption maximum: uv max (alc): 282 nm (e 7350)
 
Derivative Type: (±)-Form dihydrochloride
CAS Registry Number: 14358-43-1
Trademarks: Mebadin (Glaxo)
Molecular Formula: C29H38N2O4.2HCl
Molecular Weight: 551.54
Percent Composition: C 63.15%, H 7.31%, N 5.08%, O 11.60%, Cl 12.86%
Properties: Crystals from ethanol + ether, mp 235°.
Melting point: mp 235°
 
Derivative Type: (±)-2,3-Dehydroisoemetine hydrochloride
Properties: Crystals from ethanol + ether, mp 220-225°.
Melting point: mp 220-225°
 
Derivative Type: (-)-2,3-Dehydroisoemetine dihydrobromide
Molecular Formula: C29H38N2O4.2HBr
Molecular Weight: 640.45
Percent Composition: C 54.39%, H 6.30%, N 4.37%, O 9.99%, Br 24.95%
Properties: Crystals, mp 257-260°. [a]D -107° (methanol). uv max (alc): 285 nm (e 7400).
Melting point: mp 257-260°
Optical Rotation: [a]D -107° (methanol)
Absorption maximum: uv max (alc): 285 nm (e 7400)
 
Derivative Type: (+)-2,3-Dehydroisoemetine dihydrobromide
Properties: Crystals, mp 257-258°. [a]D +109° (methanol). uv max (alc): 285 nm (e 7450).
Melting point: mp 257-258°
Optical Rotation: [a]D +109° (methanol)
Absorption maximum: uv max (alc): 285 nm (e 7450)
 
Therap-Cat: Antiamebic.
Keywords: Antiamebic.