Home > Name List By s > Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydr...

CAS No 469-59-0 , Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-

  • Name: Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-
  • Synonyms: Jervine(8CI); Jervin;Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-,[3S-(3a,6aa,6bb,9a(3'S*,3'aR*,6'R*,7'aS*),11ab,11ba)]-;Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-; NSC 23898; Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3b,23b)-; NSC 7520;
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 3
  • Flash Point: 311.8°C
  • Boiling Point: 592°Cat760mmHg
  • Density: 1.18g/cm3
  • Refractive index: 1.59
  • Safety Statements: Poison by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. A natural toxin found in some plants. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 311.8°C
  • EINECS: 207-417-9
  • Molecular Weight: 425.67
  • InChI: InChI=1/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1
  • Risk Statements: 22
  • Molecular Formula: C27H39 N O3
  • Molecular Structure:CAS No:469-59-0 Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-

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469-59-0 JERVINE

  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
    Switzerland null,nullSwitzerland
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469-59-0 JERVINE

  • Germany BIOTREND Chemikalien GmbH [Manufacturer]
  • Tel: ++49 (0)2 21 9 49 83 20
  • Fax: ++49 (0)2 21 9 49 83 25
  • Address: BIOTREND Chemikalien GmbH
    Eupener Str. 157
    D - 50933 Cologne
    Germany null,nullGermany
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469-59-0 SC-200934 JERVINE

  • United States Santa Cruz Biotechnology, Inc. [Manufacturer]
  • Tel: 831-457-3800/ 800-457-3801
  • Fax: 831-457-3801
  • Address: Santa Cruz Biotechnology, Inc.
    2145 Delaware Ave.
    Santa Cruz, CA 95060 null,nullUnited States
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469-59-0 Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-

  • China Guangzhou WeiBo Chemical Co., Ltd. [Importer/Exporter]
  • Tel: 020-33640779 32416961
  • Fax: 020-26277554
  • Address: NO.1002-39,jinbi building,shijinshicha road,baiyun district,guanghzou city guangzhou,guangdongChina
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469-59-0 JERVINE

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany null,nullGermany
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469-59-0 JERVINE(P)

  • United States ChromaDex Inc. [Manufacturer]
  • Tel: 949-419-0288
  • Fax: 949-419-0294
  • Address: ChromaDex Inc.
    10005 Muirlands Blvd. Suite G - First Floor
    Irvine, CA 92618 null,nullUnited States
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469-59-0 Jervine

  • Switzerland Biotrend Chemicals AG [Importer/Exporter]
  • Tel: +41-(44)-805 76 76
  • Fax: +41-(44)-805 76 77
  • Address: Unterdorfstr. 21b, Wangen/Zuerich CH-8602, Wangen/Zürich,nullSwitzerland
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469-59-0 JERVINE ( (3SS,23SS)-17,23-EPOXY-3-HYDROXYVERATRAMAN-11-ONE )

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-
Title: Jervine
CAS Registry Number: 469-59-0
CAS Name: (3b,23b)-17,23-Epoxy-3-hydroxyveratraman-11-one
Molecular Formula: C27H39NO3
Molecular Weight: 425.60
Percent Composition: C 76.20%, H 9.24%, N 3.29%, O 11.28%
Literature References: Steroidal alkaloid found in Veratrum grandiflorum (Maxim.) Loes F., V. album L., V. viride Sol., Liliaceae: Saito, Bull. Chem. Soc. Jpn. 9, 15 (1934), C.A. 28, 2463 (1934); Poethke, Arch. Pharm. 275, 357, 571 (1937); 276, 170 (1938); 282, 56 (1944); Seiferle et al., J. Econ. Entomol. 35, 35 (1942); Jacobs, Craig, J. Biol. Chem. 160, 555 (1945). Structure: Fried et al., J. Am. Chem. Soc. 73, 2970 (1951). Reviews: Wintersteiner in Graff, Essays in Biochemistry (Wiley, New York, 1956) pp 308-321; idem, Festschrift Arthur Stoll (Basel, 1957) pp 166-176; L. F. Fieser, M. Fieser, Steroids (Reinhold, New York, 1959) pp 870-877. Stereochemistry: Sicher, Tichy, Tetrahedron Lett. no. 12, 6 (1959); Augustine, Chem. Ind. (London) 196l, 1448; Mitsuhashi, Shimizu, Tetrahedron 19, 1027 (1963); Bailey et al., Tetrahedron Lett. 1963, 555; Masamune et al., ibid. 1965, 489. Revised stereochemistry: Scott et al., ibid. 1967, 2381; Kupchan, Suffness, J. Am. Chem. Soc. 90, 2730 (1968); Sprague et al., Tetrahedron 27, 4857 (1971). Total synthesis: Kutney et al., Can. J. Chem. 53, 1796 (1975). Comparative toxicity: O. Krayer et al., J. Pharmacol. Exp. Ther. 82, 167 (1944); K. Tanaka, ibid. 113, 89 (1955).
Properties: Needles from methanol + water, mp 243.5-244.5° (Saito). [a]D20 -150° (ethanol) (Saito); [a]D20 -167.6° (chloroform) (Poethke). uv max: 250, 360 nm (e 15000, 60). LD50 i.v. in mice: 9.3 mg/kg (Krayer). LD50 s.c. in male mice: 29 mg/kg (Tanaka).
Melting point: mp 243.5-244.5° (Saito)
Optical Rotation: [a]D20 -150° (ethanol) (Saito); [a]D20 -167.6° (chloroform) (Poethke)
Absorption maximum: uv max: 250, 360 nm (e 15000, 60)
Toxicity data: LD50 i.v. in mice: 9.3 mg/kg (Krayer); LD50 s.c. in male mice: 29 mg/kg (Tanaka)
 
Derivative Type: Diacetyljervine
Molecular Formula: C31H43NO5
Molecular Weight: 509.68
Percent Composition: C 73.05%, H 8.50%, N 2.75%, O 15.70%
Properties: mp 173-175°. [a]D -112°. uv max (ethanol): 250, 360 nm (e 16400, 80).
Melting point: mp 173-175°
Optical Rotation: [a]D -112°
Absorption maximum: uv max (ethanol): 250, 360 nm (e 16400, 80)
 
Derivative Type: Hydrochloride
Properties: mp 300-302°.
Melting point: mp 300-302°