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CAS No 446-72-0 , 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one

  • Name: 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
  • Synonyms: Sophoricol;Prunetol; Differenol A; Genisterin;5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one; 5,7,4'-Trihydroxyisoflavone; 446-72-0; Genisteol; 4',5,7-Trihydroxyisoflavone;
  • CAS Registry Number:
  • Melting Point: 297-298 ºC
  • Density: 1.548 g/cm3
  • Refractive index: 1.732
  • Safety Statements: S24/25
  • Hazard Symbols: Xi: Irritant;
  • EINECS: 207-174-9
  • Molecular Weight: 270.2369
  • InchiKey: TZBJGXHYKVUXJN-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15
    (11)19/h1-7,16-18H
  • Risk Statements: S24/25
  • Molecular Formula: C15H10O5
  • Molecular Structure:CAS No:446-72-0 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
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446-72-0 Genistein

  • Genistein Product Name: Genistein Synonyms: 4',5,7-trihydroxyisoflavone; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one;genisteol;genisterin;prunetol CAS No.: 446-72-0 M.F.: C15H10O5 M.W.: 270.24 EINECS No.:207-174-9 Assay: 99% Packing: foil bag ...
  • China Hubei Yuancheng Saichuang Technology Co.Ltd [Manufacturer]
  • Tel: 86-027-50756140
  • Address: Zhongshan Road Wuhan,HubeiChina
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446-72-0 Genistein

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  • China WuhanYuanchengGongchuang Techology Co.Ltd [Manufacturer, Trading Company]
  • Tel: 86-027-50756153
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  • Address: No.496,Zhongshan Road, Wuhan, Hubei, China Wuhan,HubeiChina
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446-72-0 Genistein

  • Product Name: Genistein Synonyms: 4',5,7-trihydroxyisoflavone; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one;genisteol;genisterin;prunetol CAS No.: 446-72-0 M.F.: C15H10O5 M.W.: 270.24 EINECS No.:207-174-9 Assay: 99% Packing: foil bag Appearance...
  • Min. Order: 1000
  • FOB Price: USD1 - 2 /
  • China Hubei Yuancheng Saichuang Technology Co.,Ltd [Manufacturer]
  • Tel: 86-027-50755973
  • Address: No.496,Zhongshan Road,Wuchang District Wuhan,HubeiChina
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446-72-0 Genistein

  • Synonyms: differenola;genistein(synthetic);genisteol;genisterin;prunetol CAS: 446-72-0 MF: C15H10O5 MW: 270.24 EINECS: 207-174-9 mp 297-298 °C storage temp. ?20°C solubility DMSO: soluble Chemical Properties Yellow Crystalline Solid Usage: Exhibits s...
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  • China Hubei Yuancheng Saichuang Technology Co., Ltd. [Manufacturer, Trading Company]
  • Tel: 86-027-50756244
  • Fax: --
  • Address: 496# Zhongshan Road,Wuchang, Wuhan,Hubei,China wuhan ,HubeiChina
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446-72-0 Genistein

  • China Syntechem Co.,Ltd [Manufacturer]
  • Tel: +86-519-89882658
  • Fax: +86-519-8512 5369
  • Address: Syntechem Co.,Ltd
    18 South Zhulin Rd.
    Tianning district,Changzhou
    Jiangsu China 213022 null,nullChina
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446-72-0 Genistein

  • Genistein5,7,4'-Trihydroxyisoflavone, 98%
  • United States INDOFINE Chemical Co., Inc. [Manufacturer]
  • Tel: (908) 359-6778
  • Fax: (908) 359-1179
  • Address: 121 Stryker Lane
    Bldg 30, Suite 1
    Hillsborough, NJ 08844 null,nullUnited States
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446-72-0 Genistein

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi null,ShanXiChina
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446-72-0 Genistein

  • China Xilin Chemical Group Co., Ltd null
  • Tel: +86-(0)-15527136576
  • Fax: +86-(27)-83820093
  • Address: 16# Luojiashan, Wuchang District, Wuhan, Hubei 430071, null,nullChina
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446-72-0 Genistein

  • Genistein Product Name: Genistein Name: Genistein English alias: 4 ',5,7-Trihydroxyisoflavone CAS :446-72-0 Packaging: 25kg cardboard drum Specifications Model: 99% MF: C15H10O5 MW: 270.24 EINECS No.: 207-174-9 Water-soluble insoluble Melting point: ...
  • Min. Order: 120
  • China Hubei Datong Bio-Chemical Technology Co., Ltd. [Manufacturer]
  • Tel: 86-27-87666702
  • Fax: 86-27-87666702
  • Address: Gold Bridge of Macheng City Economic Development Zone. Huanggang,HubeiChina

446-72-0 Genistein

  • Genistein
  • Hong kong Frapp's Pharma (Hongkong) Co.,Ltd [Manufacturer]
  • Tel: +852 8130 0917
  • Fax: +852 8130 0927
  • Address: Room 801,Mongkok Harbour Centre,638 Shanghai Street,Mongkok,Kowloon,Hongkang518001 MongkokHONG KONG Mongkok,nullHong kong
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References of 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
Title: Genistein
CAS Registry Number: 446-72-0
CAS Name: 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Synonyms: 4¢,5,7-trihydroxyisoflavone; prunetol; genisteol
Molecular Formula: C15H10O5
Molecular Weight: 270.24
Percent Composition: C 66.67%, H 3.73%, O 29.60%
Literature References: Phytoestrogen found in soy products; the aglucon of genistin and of sophoricoside. Specific protein kinase inhibitor. Prepn from the glucoside by hydrolysis with emulsin: Charaux, Rabaté, J. Pharm. Chim. [9] 1, 404 (1941); by hydrolysis with HCl in methanol: Walter, J. Am. Chem. Soc. 63, 3273 (1941). Isoln from prunus spp., Rosaceae: Hasegawa ibid. 79, 1738 (1957); from Podocarpus spicata R.Br., Podocarpaceae: Briggs, Cebalo, Tetrahedron 6, 145 (1959). Structure: Baker, Robinson, J. Chem. Soc. 1925, 1981; 1926, 2713; Walz, Ann. 489, 118 (1931). Synthesis: Baker, Robinson, J. Chem. Soc. 1928, 3115; Narasimhachari et al., J. Sci. Ind. Res. 12, 287 (1953); Yoder et al., Proc. Iowa Acad. Sci. 61, 271 (1954); Zemplén et al., Acta Chim. Acad. Sci. Hung. 19, 277 (1959). HPLC determn in biological fluids: J. G. Supko, L. R. Phillips, J. Chromatogr. B 666, 157 (1995); A. A. Franke et al, Proc. Soc. Exp. Biol. Med. 208, 18 (1995). Review of synthesis and isotopic labeling: K. W?h?l? et al., ibid. 27-32. Series of articles on chemopreventive properties and mechanism of action: ibid. 103-115, 120-130; J. Nutr. 125, Suppl. 3, 777S-797S (1995).
Properties: Rectangular or six-sided rods from 60% alcohol. Dendritic needles from ether. mp 297-298° (slight decompn). Sol in the usual organic solvents, in dil alkalies with yellow color. Practically insol in water. uv max: 262.5 nm (e 138).
Melting point: mp 297-298° (slight decompn)
Absorption maximum: uv max: 262.5 nm (e 138)
 
Derivative Type: Sophoricoside
CAS Registry Number: 152-95-4
Synonyms: Genistein-4¢-glucoside
Molecular Formula: C21H20O10
Molecular Weight: 432.38
Percent Composition: C 58.33%, H 4.66%, O 37.00%
Literature References: From the green pods of Sophora japonica L., Leguminosae: Charaux, Rabate, Bull. Soc. Chim. Biol. 20, 454 (1938). Structure: Zemplén et al., Ber. 76, 267 (1943). Synthesis: Bognár, Szabo, Acta Chim. Acad. Sci. Hung. 4, 383 (1954); Chem. Ind. (London) 1954, 518.
Properties: Crystals from alcohol, mp 298°. [a]D20 -47° (pyridine). [a]D20 -32° (10% aq pyridine). uv max (abs ethanol): 262 nm. Sparingly sol in water, alc, acetic acid; more sol in hot alc, hot acetic acid; sol in pyridine, dil alkalies. Practically insol in ethyl acetate, acetone.
Melting point: mp 298°
Optical Rotation: [a]D20 -47° (pyridine); [a]D20 -32° (10% aq pyridine)
Absorption maximum: uv max (abs ethanol): 262 nm
 
Derivative Type: Genistin
CAS Registry Number: 529-59-9
Synonyms: Genistein-7-O-b-D-glucoside
Molecular Formula: C21H20O10
Molecular Weight: 432.38
Percent Composition: C 58.33%, H 4.66%, O 37.00%
Literature References: For isoln and structure see Walter, Hasegawa, Walz, loc. cit. Synthesis: Zemplén, Farkas, Ber. 76B, 1110 (1943).
Properties: Pale yellow plates from 80% ethanol, mp 256°. [a]D21 -28° (c = 0.6 in 0.02N NaOH); [a]D26 -21.4° (pyridine). uv max (85% ethanol): 262.5 nm (a 90.5). Practically insol in cold water. Slightly sol in hot water, hot ethanol, hot methanol; sol in hot 80% ethanol, hot 80% methanol, hot acetone, pyridine.
Melting point: mp 256°
Optical Rotation: [a]D21 -28° (c = 0.6 in 0.02N NaOH); [a]D26 -21.4° (pyridine)
Absorption maximum: uv max (85% ethanol): 262.5 nm (a 90.5)
 
Derivative Type: Olmelin
Synonyms: 5,7-Dihydroxy-4¢-methoxyisoflavone; biochanin A; 4¢-methyl ether
Molecular Formula: C16H12O5
Molecular Weight: 284.26
Percent Composition: C 67.60%, H 4.26%, O 28.14%
Literature References: Isoln from red clover: Pope et al., Chem. Ind. (London) 1953, 1092; Wong, J. Sci. Food Agric. 13, 304 (1962); from Andira inermis (Swartz) H.B.K., Leguminosae: Crocker et al., J. Chem. Soc. 1962, 4906. Identity with olmelin: Gakhokidze, J. Appl. Chem. USSR 23, 789 (1950), C.A. 46, 9098i (1952). Structure: Bose, Siddiqui, J. Sci. Ind. Res. 9B, no. 1, 25 (1950). Synthesis: Baker et al., Nature 169, 706 (1952).
Properties: Yellow needles from methanol, mp 212-216°.
Melting point: mp 212-216°
 
Use: Chemical probe to explore signal transduction pathways.