Home > Name List By 7 > 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1-(2-hydroxyethyl)-3H-1, 4-benzodiazepin-2-one

CAS No 40762-15-0 , 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1-(2-hydroxyethyl)-3H-1,
4-benzodiazepin-2-one

  • Name: 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1-(2-hydroxyethyl)-3H-1,
    4-benzodiazepin-2-one
  • Synonyms: Doxefazepamum [INN-Latin]; Doxefazepam [INN];7-chloro-5-(2-fluorophenyl)-3-hydroxy-1-(2-hydroxyethyl)-3H-1,
    4-benzodiazepin-2-one; Doxefazepam (INN);Doxans; N-1-Hydroxyethyl-3-hydroxyflurazepam; CCRIS 3705; Sas 643;
  • CAS Registry Number:
  • Transport: 3249
  • Flash Point: 327.8°C
  • Boiling Point: 618.4°Cat760mmHg
  • Density: 1.45g/cm3
  • Refractive index: 1.646
  • Safety Statements: Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by an unspecified route: somnolence. When heated to decomposition it emits very toxic fumes of Cl−, F−, and NOx.
  • Flash Point: 327.8°C
  • Molecular Weight: 348.756063
  • InchiKey: VOJLELRQLPENHL-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H14ClFN2O3/c18-10-5-6-14-12(9-10)15(11-3-1-2-4-13(11)19)20-
    16(23)17(24)21(14)7-8-22/h1-6,9,16,22-23H,7-8H2
  • Molecular Formula: C17H14ClFN2O3
  • Molecular Structure:CAS No:40762-15-0 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1-(2-hydroxyethyl)-3H-1,<br />4-benzodiazepin-2-one

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References of 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1-(2-hydroxyethyl)-3H-1,
4-benzodiazepin-2-one
Title: Doxefazepam
CAS Registry Number: 40762-15-0
CAS Name: 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-1-(2-hydroxyethyl)-2H-1,4-benzodiazepin-2-one
Synonyms: N-1-hydroxyethyl-3-hydroxyflurazepam
Manufacturers' Codes: SAS-643
Trademarks: Doxans (Schiapparelli)
Molecular Formula: C17H14ClFN2O3
Molecular Weight: 348.76
Percent Composition: C 58.55%, H 4.05%, Cl 10.17%, F 5.45%, N 8.03%, O 13.76%
Literature References: Prepn: G. F. Tamagnone et al., Arzneim.-Forsch. 25, 720 (1975); eidem, J. Pharm. Pharmacol. 26, 566 (1974); F. De Marchi, G. F. Tamagnone, DE 2338058 (1974 to Schiapparelli), C.A. 80, 121016v (1974). Comparison with flurazepam, q.v., and pharmacology, toxicity studies: M. Babbini et al., Arzneim.-Forsch. 25, 1294 (1975). Structure-activity studies: eidem, Pharmacol. Res. Commun. 7, 337 (1975). GC determn in blood and tissue: F. Marcucci et al., J. Chromatogr. 198, 180 (1980); in plasma, urine: S. Mardente et al., Ther. Drug Monit. 3, 351 (1981). Quantitative EEG, behavioral effects: W. G. Sanita et al., ibid. 341. Effect on sleep: G. Rodriguez et al., Neuropsychobiology 11, 133 (1984).
Properties: Crystals from methylene chloride/petr ether, mp 138-140°. LD50 in rats, mice (mg/kg): 2550, >1500 orally; 586, 774 i.p. (Babbini).
Melting point: mp 138-140°
Toxicity data: LD50 in rats, mice (mg/kg): 2550, >1500 orally; 586, 774 i.p. (Babbini)
Therap-Cat: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Benzodiazepine Derivatives.