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CAS No 26973-24-0 , (6R,7R)-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-3-(1,3,
4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
carboxylic acid Search by region : India

  • Name: (6R,7R)-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-3-(1,3,
    4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
    carboxylic acid
  • Synonyms: Ceftezol; CG-B 3 Q;Ceftezolum; 26973-24-0; Ceftezolo; Demethylcefazolin;(6R,7R)-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-3-(1,3,
    4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
    carboxylic acid; Ceftezole (INN); AC1Q6LOU; NCGC00182064-02;
  • CAS Registry Number:
  • Melting Point: 155 ºC (DEC.)
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 2.09
  • Refractive index: 2.003
  • Flash Point: °C
  • Molecular Weight: 440.48058
  • InchiKey: DZMVCVMFETWNIU-LDYMZIIASA-N
  • InChI: InChI=1S/C13H12N8O4S3/c22-7(1-20-4-14-18-19-20)16-8-10(23)21-9(12(24)25)
    6(2-26-11(8)21)3-27-13-17-15-5-28-13/h4-5,8,11H,1-3H2,(H,16,22)(H,24,
    25)/t8-,11-/m1/s1
  • Molecular Formula: C13H12N8O4S3
  • Molecular Structure:CAS No:26973-24-0 (6R,7R)-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-3-(1,3,<br />4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-<br />carboxylic acid

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References of (6R,7R)-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-3-(1,3,
4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
carboxylic acid
Title: Ceftezole
CAS Registry Number: 26973-24-0
CAS Name: (6R,7R)-8-Oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms: 7-(1H-tetrazol-1-yl)acetamido-3-(1,3,4-thiadiazol-2-ylthio)methylceph-3-em-4-carboxylic acid; CTZ
Manufacturers' Codes: CG-B3Q
Molecular Formula: C13H12N8O4S3
Molecular Weight: 440.48
Percent Composition: C 35.45%, H 2.75%, N 25.44%, O 14.53%, S 21.84%
Literature References: Broad spectrum antibiotic similar to cefazolin, q.v. Prepn: T. Takano et al., ZA 6804513; eidem, US 3516997 (1969, 1970 both to Fujisawa). In vitro and in vivo activity: T. Noto et al., J. Antibiot. 29, 1058 (1976). Pharmacology: Y. Harada et al., ibid. 1071; M. Kakimoto et al., Chemotherapy (Tokyo) 24, 722 (1976). Metabolism: K. Koyama et al., ibid. 619; Y. Tohira et al., ibid. 655. Clinical study: S. Ishiyama et al., ibid. 1006. Toxicity and teratogenicity studies: R. Niki et al., ibid. 671.
Properties: Solid, mp 155° (dec). uv max (phosphate buffer pH 6.4): 273 nm (E1%1cm 274).
Melting point: mp 155° (dec)
Absorption maximum: uv max (phosphate buffer pH 6.4): 273 nm (E1%1cm 274)
 
Derivative Type: Sodium salt
CAS Registry Number: 41136-22-5
Manufacturers' Codes: FR-10123
Trademarks: Celoslin (Hoechst); Falomesin (Chugai)
Molecular Formula: C13H11N8NaO4S3
Molecular Weight: 462.46
Percent Composition: C 33.76%, H 2.40%, N 24.23%, Na 4.97%, O 13.84%, S 20.80%
Properties: White solid, freely sol in water.
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.