Home > Name List By other > (6R,7R)-7-[[2-(2-amino-1, 3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5- yl]sulfanylmethyl]-8-oxo-5-t...

CAS No 61622-34-2 , (6R,7R)-7-[[2-(2-amino-1,
3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-
yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
carboxylic acid

  • Name: (6R,7R)-7-[[2-(2-amino-1,
    3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-
    yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
    carboxylic acid
  • Synonyms: 61622-34-2;(6R,7R)-7-[[2-(2-amino-1,
    3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-
    yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
    carboxylic acid; Haloapor;Cefotiamum; Ceradon; CGP 14221E; Cefotiamum [INN-Latin]; CEFOTIAM HYDROCHLORIDE; Ceradolan;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.8 g/cm3
  • Refractive index: 1.855
  • Flash Point: °C
  • Molecular Weight: 525.62812
  • InchiKey: QYQDKDWGWDOFFU-IUODEOHRSA-N
  • InChI: InChI=1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14
    (29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,
    1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1
  • Molecular Formula: C18H23N9O4S3
  • Molecular Structure:CAS No:61622-34-2 (6R,7R)-7-[[2-(2-amino-1,<br />3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-<br />yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-<br />carboxylic acid

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References of (6R,7R)-7-[[2-(2-amino-1,
3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-
yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
carboxylic acid
Title: Cefotiam
CAS Registry Number: 61622-34-2
CAS Name: (6R,7R)-7-[[(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]-thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms: 7b-[2-(aminothiazol-4-yl)acetamido]-3-[[[1-(2-dimethylaminoethyl)-1H-tetrazol-5-yl]thio]methyl]ceph-3-em-4-carboxylic acid
Manufacturers' Codes: SCE-963
Molecular Formula: C18H23N9O4S3
Molecular Weight: 525.63
Percent Composition: C 41.13%, H 4.41%, N 23.98%, O 12.18%, S 18.30%
Literature References: Semi-synthetic cephalosporin antibiotic. Prepn: S. Terao et al., DE 2458695; M. Numata et al., US 4080498 (1975, 1978 both to Takeda); eidem, J. Antibiot. 31, 1262 (1978). Prepn of the crystalline dihydrochloride: K. Naito et al., DE 2738711; eidem, US 4146710 (1978, 1979 both to Takeda). Pharmacodynamics: K. Tsuchiya et al., ibid., 1272. Antibacterial spectrum: eidem, Antimicrob. Agents Chemother. 14, 557 (1978). Clinical trial in respiratory infections: H. M. Beumer et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 23, 105 (1985).
 
Derivative Type: Dihydrochloride
CAS Registry Number: 66309-69-1
Manufacturers' Codes: Abbott 48999; CGP-14221/E
Trademarks: Halospor (Novartis); Pansporin (Takeda); Pansporine (Cassenne-Takeda); Spizef (Grñenthal); Sporidyn (Cyanamid)
Molecular Formula: C18H23N9O4S3.2HCl
Molecular Weight: 598.55
Percent Composition: C 36.12%, H 4.21%, N 21.06%, O 10.69%, S 16.07%, Cl 11.85%
Properties: White to light yellow crystals. Sol in methanol. Slightly sol in ethanol.
 
Derivative Type: 1-(Cyclohexyloxycarbonyloxy)ethyl ester dihydrochloride
CAS Registry Number: 95789-30-3
Synonyms: Cefotiam hexetil hydrochloride
Manufacturers' Codes: SCE-2174
Trademarks: Pansporin T (Takeda); Taketiam (Takeda); Texodil (Cassenne)
Molecular Formula: C27H37N9O7S3.2HCl
Molecular Weight: 768.76
Percent Composition: C 42.18%, H 5.11%, N 16.40%, O 14.57%, S 12.51%, Cl 9.22%
Literature References: Prepn: T. Nishimura et al., EP 128029; eidem, US 5120841 (1984, 1992 both to Takeda); eidem et al., J. Antibiot. 40, 81 (1987). Acute toxicity: S. Chiba et al., Oyo Yakuri 35, 179 (1988), C.A. 109, 31615c (1988). Clinical trial: H. Maier et al. Arzneim.-Forsch. 42, 980 (1992).
Properties: Colorless powder. Soly in water at pH 4.5: >1 mg/ml. LD50 in male, female mice, male, female rats (mg/kg): 1290, 1150, 1470, 1620 i.p.; >2000 s.c.; >5000 orally (Chiba).
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 1290, 1150, 1470, 1620 i.p.; >2000 s.c.; >5000 orally (Chiba)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.