Home > Name List By other > [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6, 9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15, 16-oc...

CAS No 23674-86-4 , [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,
9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,
16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate

  • Name: [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,
    9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,
    16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
  • Synonyms: Difluoroprednisolone butyrate acetate; 6ALPHA,9ALPHA-DIFLUOROPREDNISOLONE 21-ACETATE 17-BUTYRATE;Durezol; Epitopic; 23674-86-4; DFBA;[(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,
    9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,
    16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate; Myser;
  • CAS Registry Number:
  • Melting Point: 192 - 194
  • Flash Point: 316.9 ºC
  • Boiling Point: 600.3 ºC
  • Density: 1.29 g/cm3
  • Refractive index: 1.544
  • Safety Statements: Poison by subcutaneous and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F−.
  • Flash Point: 316.9 ºC
  • EINECS: 245-815-4
  • Molecular Weight: 508.551466
  • InchiKey: WYQPLTPSGFELIB-JTQPXKBDSA-N
  • InChI: InChI=1S/C27H34F2O7/c1-5-6-23(34)36-26(22(33)14-35-15(2)30)10-8-17-18-
    12-20(28)19-11-16(31)7-9-24(19,3)27(18,29)21(32)13-25(17,26)4/h7,9,11,
    17-18,20-21,32H,5-6,8,10,12-14H2,1-4H3/t17-,18-,20-,21-,24-,25-,26-,
    27-/m0/s1
  • Molecular Formula: C27H34F2O7
  • Molecular Structure:CAS No:23674-86-4 [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,<br />9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,<br />16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate

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References of [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,
9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,
16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
Title: Difluprednate
CAS Registry Number: 23674-86-4
CAS Name: (6a,11b)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dione
Synonyms: 6a,9-difluoro-11b,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate 17-butyrate; 6a,9a-difluoroprednisolone-21-acetate-17-butyrate
Manufacturers' Codes: CM-9155; W-6309
Trademarks: Epitopic (Gerda); Myser (Nikken)
Molecular Formula: C27H34F2O7
Molecular Weight: 508.55
Percent Composition: C 63.77%, H 6.74%, F 7.47%, O 22.02%
Literature References: Prepn: A. Ercoli, R. Gardi, ZA 6803686; A. Ercoli et al., US 3780177 (1968, 1973 both to Warner-Lambert). Anti-inflammatory properties: G. Di Pasquale et al., Steroids 16, 663, 679 (1970); R. Gardi et al., J. Med. Chem. 15, 556 (1972). Pharmacological study: J. Navarro et al., Arzneim.-Forsch. 28, 2302 (1978). Vasoconstrictive activity in man: A. Barbier et al., Therapie 33, 607 (1978). Bioavailability study: C. Lafille et al., Dermatologica 159, 277 (1979).
Properties: Crystals from methylene chloride/ether/petr ether, mp 191-194°. [a]D22 +31.7° (c = 0.5 in dioxane). uv max (ethanol): 237-238 nm (E1%1cm 320).
Melting point: mp 191-194°
Optical Rotation: [a]D22 +31.7° (c = 0.5 in dioxane)
Absorption maximum: uv max (ethanol): 237-238 nm (E1%1cm 320)
Therap-Cat: Anti-inflammatory.
Keywords: Glucocorticoid.