CAS No 20229-30-5 , Piperazine,1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methyl-

Name: Piperazine,1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methyl-
Synonyms: Methiotepin; Methiothepine; Metitepine;Dibenzo[b,f]thiepin,piperazine deriv.; Ro8-6837; Methiothepin;Piperazine,1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methyl-;
CAS Registry Number:20229-30-5
Melting Point: 356.548
Flash Point: 233.8°C
Boiling Point: 462.9°Cat760mmHg
Density: 1.25g/cm³
Safety Statements: WGK Germany 3
Flash Point: 233.8°C
Molecular Weight: 472.62
InchiKey: RLJFTICUTYVZDG-UHFFFAOYSA-N
InChI: InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3
Molecular Formula: C24H28N2O4S2
Molecular Structure:

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References of Piperazine,1-[10,11-dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methyl-

Title: Metitepine
CAS Registry Number: 20229-30-5
CAS Name: 1-[10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl]-4-methylpiperazine
Synonyms: 8-methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepine; methiothepine; methiothepin
Manufacturers' Codes: Ro-8-6837
Molecular Formula: C20H24N2S2
Molecular Weight: 356.55
Percent Composition: C 67.37%, H 6.78%, N 7.86%, S 17.99%
Literature References: Serotonin (5-HT2) receptor antagonist; also exhibits affinity for 5-HT1-receptors. Prepn: NL 6608618; M. Protiva et al., US 3379729 (1966, 1968 both to SPOFA); and pharmacology: K. Pelz et al., Collect. Czech. Chem. Commun. 33, 1895 (1968); J. O. Jilek et al., ibid. 39, 3338 (1974). Receptor-blocking study: M.-A. Monachon et al., Arch. Pharmacol. 274, 192 (1972). Use in classification of 5-HT receptors: P. B. Bradley et al., Neuropharmacology 25, 563 (1986); E. J. Mylecharane, Clin. Exp. Pharmacol. Physiol. 16, 517 (1989).
Properties: Crystals from ethanol, mp 88-89°.
Melting point: mp 88-89°

Derivative Type: Maleate
CAS Registry Number: 19728-88-2
Molecular Formula: C20H24N2S2.C4H4O4
Molecular Weight: 472.62
Percent Composition: C 60.99%, H 5.97%, N 5.93%, S 13.57%, O 13.54%
Properties: Crystals from ethanol, mp 171-173°. LD5O in mice (mg/kg): 51 i.v.; 94 orally (Jilek).
Melting point: mp 171-173°
Toxicity data: LD5O in mice (mg/kg): 51 i.v.; 94 orally (Jilek)

Use: Biochemical tool in serotonin receptor binding studies.