Home > Name List By 2 > 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4, 3-a]pyridin-3-one China

CAS No 19794-93-5 , 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,
3-a]pyridin-3-one Search by region : China

  • Name: 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,
    3-a]pyridin-3-one
  • Synonyms: Molipaxin; Trazodon;Beneficat; Sideril;2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,
    3-a]pyridin-3-one; Trazonil; Trazodil; Desirel; Trazalon; Trittico;
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 86-870C
  • Flash Point: 273.4°C
  • Boiling Point: 528.5°Cat760mmHg
  • Density: 1.33g/cm3
  • Refractive index: 1.67
  • Safety Statements: Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Human systemic effects: cholestatic jaundice. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl− and NOx.
  • Hazard Symbols: UN NO.
  • Flash Point: 273.4°C
  • EINECS: 243-317-1
  • Molecular Weight: 371.86388
  • InchiKey: PHLBKPHSAVXXEF-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-
    25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2
  • Molecular Formula: C19H22ClN5O
  • Molecular Structure:CAS No:19794-93-5 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,<br />3-a]pyridin-3-one

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References of 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,
3-a]pyridin-3-one
Title: Trazodone
CAS Registry Number: 19794-93-5
CAS Name: 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one
Molecular Formula: C19H22ClN5O
Molecular Weight: 371.86
Percent Composition: C 61.37%, H 5.96%, Cl 9.53%, N 18.83%, O 4.30%
Literature References: Prepn: Palazzo, Silvestrini, US 3381009 (1968 to Angelini Francesco). Pharmacology: Catanese, Lisciani, Boll. Chim. Farm. 109, 369 (1970); B. Silvestrini, E. Quadri, Eur. J. Pharmacol. 12, 231 (1970). Analytical data: Baiocchi et al., Arzneim.-Forsch. 23, 400 (1973). Crystal structure: J. P. Fillers, S. W. Hawkinson, Acta Crystallogr. B35, 498 (1979). Review of pharmacological properties and therapeutic use: R. N. Brogden et al., Drugs 21, 401-429 (1981); B. Silvestrini et al., in Pharmacological and Biochemical Properties of Drug Substances vol. 3, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1981) pp 94-119. Comprehensive description: D. Gorecki, R. Verbeeck, Anal. Profiles Drug Subs. 16, 693-729 (1986). Symposium on clinical efficacy: Psychopharmacology 95, Suppl., 1-56 (1988).
Properties: Crystals, mp 86-87°. Also reported as mp 96° (Baiocchi). pKa (50% ethanol): 6.14.
Melting point: mp 86-87°; mp 96° (Baiocchi)
pKa: pKa (50% ethanol): 6.14
 
Derivative Type: Hydrochloride
CAS Registry Number: 25332-39-2
Manufacturers' Codes: AF-1161
Trademarks: Bimaran (Roux-Ocefa); Desyrel (Apothecon); Molipaxin (HMR); Pragmazone (UPSA); Thombran (Thomae); Tombran (Boehringer, Ing.); Trazolan (Continental Pharma); Trittico (Angelini)
Molecular Formula: C19H22ClN5O.HCl
Molecular Weight: 408.32
Percent Composition: C 55.89%, H 5.68%, Cl 17.37%, N 17.15%, O 3.92%
Properties: White, odorless plates from ethanol, mp 223°. Soluble in chloroform; sparingly sol in water, ethanol, methanol. Practically insol in common organic solvents. uv max (water): 211, 246, 274, 312 nm (e 50100, 11730, 3840, 3840). LD50 i.v. in mice: 96 mg/kg (Silvestrini, Quadri).
Melting point: mp 223°
Absorption maximum: uv max (water): 211, 246, 274, 312 nm (e 50100, 11730, 3840, 3840)
Toxicity data: LD50 i.v. in mice: 96 mg/kg (Silvestrini, Quadri)
 
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Bicyclics.