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CAS No 82-95-1 , 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenylmethyl]
piperazine

  • Name: 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenylmethyl]
    piperazine
  • Synonyms: 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenylmethyl]
    piperazine; Buclodin; Histabutizine; Buclizinum [INN-Latin]; Bucladin; Aphilan-R base; Histabutyzine; Histabuticine;Vibazine; Buclifen;
  • CAS Registry Number:
  • Safety Statements: Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx and Cl−.
  • EINECS: 201-448-1
  • Molecular Weight: 433.02802
  • InchiKey: MOYGZHXDRJNJEP-UHFFFAOYSA-N
  • InChI: InChI=1S/C28H33ClN2/c1-28(2,
    3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-
    15-26(29)16-12-24/h4-16,27H,17-21H2,1-3H3
  • Molecular Formula: C28H33ClN2
  • Molecular Structure:CAS No:82-95-1 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenylmethyl]<br />piperazine

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References of 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenylmethyl]
piperazine
Title: Buclizine
CAS Registry Number: 82-95-1
CAS Name: 1-[(4-Chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]piperazine
Synonyms: 1-(p-tert-butylbenzyl)-4-(p-chloro-a-phenylbenzyl)piperazine; 1-(p-chlorobenzhydryl)-4-(p-tert-butylbenzyl)diethylenediamine; 1-(p-tert-butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazine; histabutyzine; histabutizine
Molecular Formula: C28H33ClN2
Molecular Weight: 433.03
Percent Composition: C 77.66%, H 7.68%, Cl 8.19%, N 6.47%
Literature References: Prepn: Morren, US 2709169 (1955 to U.C.B.), see also DE 964040, Lui et al., C.A. 62, 2776a (1965). Clinical evaluation as antiemetic in migraine: P. B. Jorgensen et al., Curr. Ther. Res. 16, 1276 (1974); E. I. Adam, J. Int. Med. Res. 15, 71 (1987).
Properties: bp0.001 217-220°.
Boiling point: bp0.001 217-220°
 
Derivative Type: Dihydrochloride
CAS Registry Number: 129-74-8
Manufacturers' Codes: UCB-4445
Trademarks: Aphilan (UCB); Buclina (Sanofi-Synthelabo); Longifene (UCB); Postafen (UCB)
Molecular Formula: C28H33ClN2.2HCl
Molecular Weight: 505.95
Percent Composition: C 66.47%, H 6.97%, Cl 21.02%, N 5.54%
Properties: mp 230-240°.
Melting point: mp 230-240°
 
Therap-Cat: Antiemetic.
Keywords: Antiemetic.