Home > Name List By 3 > 3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2, 4]triazolo[4,3-a]pyridine

CAS No 72822-12-9 , 3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,
4]triazolo[4,3-a]pyridine

  • Name: 3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,
    4]triazolo[4,3-a]pyridine
  • Synonyms: Dapiprazol [German]; Dapirazolum;3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,
    4]triazolo[4,3-a]pyridine; Dapiprazole [INN]; Dapirazol; Glamidolo;Dapiprazol; Rev-Eyes; Reversil; dapiprazolum;
  • CAS Registry Number:
  • Flash Point: 279.7 ºC
  • Boiling Point: 538.9 ºC at 760 mmHg
  • Density: 1.22 g/cm3
  • Refractive index: 1.658
  • Flash Point: 279.7 ºC
  • Molecular Weight: 325.45118
  • InchiKey: RFWZESUMWJKKRN-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H27N5/c1-16-6-2-3-7-17(16)23-14-12-22(13-15-23)11-9-19-21-
    20-18-8-4-5-10-24(18)19/h2-3,6-7H,4-5,8-15H2,1H3
  • Molecular Formula: C19H27N5
  • Molecular Structure:CAS No:72822-12-9 3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,<br />4]triazolo[4,3-a]pyridine

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72822-12-9 1,2,4-Triazolo[4,3-a]pyridine,5,6,7,8-tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-

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References of 3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,
4]triazolo[4,3-a]pyridine
Title: Dapiprazole
CAS Registry Number: 72822-12-9
CAS Name: 5,6,7,8-Tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-1,2,4-triazolo[4,3-a]pyridine
Synonyms: 5,6,7,8-tetrahydro-3-[2-(4-o-tolyl-1-piperazinyl)ethyl]-s-triazolo[4,3-a]pyridine
Molecular Formula: C19H27N5
Molecular Weight: 325.45
Percent Composition: C 70.12%, H 8.36%, N 21.52%
Literature References: a-Adrenergic blocker. Prepn: B. Silvestrini, L. Baiocchi, DE 2915318; eidem, US 4252721 (1979, 1981 both to Angelini Francesco). Series of articles on general pharmacology: Arzneim.-Forsch. 32, 674-681 (1982); and toxicity: B. Silvestrini et al., ibid. 668. Ocular pharmacokinetics in rabbits: P. Valeri et al., Pharmacol. Res. Commun. 18, 1093 (1986). Topical effects in human eye: A. Reibaldi et al., Acta Ther. 10, 381 (1984); C. Malpassi et al., ibid. 12, 55 (1986). Clinical trial in reversal of mydriasis: R. W. Allinson et al., Ann. Ophthalmol. 22, 131 (1990).
Properties: mp 158-160°.
Melting point: mp 158-160°
 
Derivative Type: Monohydrochloride
CAS Registry Number: 72822-13-0
Manufacturers' Codes: AF-2139
Trademarks: Glamidolo (Angelini); Reversil (Angelini); Rev-Eyes (Angelini)
Molecular Formula: C19H27N5.HCl
Molecular Weight: 361.91
Percent Composition: C 63.06%, H 7.80%, N 19.35%, Cl 9.80%
Properties: Crystals from absolute ethanol, mp 206-207°. LD50 in mice (mg/kg): 260 i.p. (Silvestrini).
Melting point: mp 206-207°
Toxicity data: LD50 in mice (mg/kg): 260 i.p. (Silvestrini)
 
Therap-Cat: Antiglaucoma; miotic.
Keywords: a-Adrenergic Blocker; Antiglaucoma.