Home > Name List By 4 > 4-[(1,1-dioxo-1,2,4-thiadiazinan-4-yl)methyl]-1,2,4-thiadiazinane 1,1-dioxide

CAS No 19388-87-5 , 4-[(1,1-dioxo-1,2,4-thiadiazinan-4-yl)methyl]-1,2,4-thiadiazinane
1,1-dioxide

  • Name: 4-[(1,1-dioxo-1,2,4-thiadiazinan-4-yl)methyl]-1,2,4-thiadiazinane
    1,1-dioxide
  • Synonyms: 4-[(1,1-dioxo-1,2,4-thiadiazinan-4-yl)methyl]-1,2,4-thiadiazinane
    1,1-dioxide; Taurolidina [INN-Spanish]; EINECS 243-016-5;Taurolin; Tauroline; 19388-87-5; Taurolidinum [INN-Latin];
  • CAS Registry Number:
  • Melting Point: 156
  • Density: 1.466 g/cm3
  • Refractive index: 1.564
  • EINECS: 243-016-5
  • Molecular Weight: 284.35634
  • InchiKey: AJKIRUJIDFJUKJ-UHFFFAOYSA-N
  • InChI: InChI=1S/C7H16N4O4S2/c12-16(13)3-1-10(5-8-16)7-11-2-4-17(14,
    15)9-6-11/h8-9H,1-7H2
  • Molecular Formula: C7H16N4O4S2
  • Molecular Structure:CAS No:19388-87-5 4-[(1,1-dioxo-1,2,4-thiadiazinan-4-yl)methyl]-1,2,4-thiadiazinane<br />1,1-dioxide

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References of 4-[(1,1-dioxo-1,2,4-thiadiazinan-4-yl)methyl]-1,2,4-thiadiazinane
1,1-dioxide
Title: Taurolidine
CAS Registry Number: 19388-87-5
CAS Name: 4,4￠-Methylenebis(tetrahydro-1,2,4-thiadiazine) 1,1,1￠,1￠-tetraoxide
Synonyms: 4,4￠-methylenebis(perhydro-1,2,4-thiadiazine 1,1-dioxide); bis(1,1-dioxoperhydro-1,2,4-thiadiazin-4-yl)methane
Trademarks: Drainasept (Geistlich); Taurolin (HMR); Tauroflex (Geistlich)
Molecular Formula: C7H16N4O4S2
Molecular Weight: 284.36
Percent Composition: C 29.57%, H 5.67%, N 19.70%, O 22.51%, S 22.55%
Literature References: Broad spectrum, synthetic formaldehyde carrier formed by the condensation of two molecules of taurine and three molecules of formaldehyde. Prepn: FR 1458701; R. W. Pfirrmann, US 3423408 (1966, 1969 both to Ed. Geistlich S?hne). Antibacterial activity in mice: M. K. Browne et al., J. Appl. Bacteriol. 41, 363 (1976). Anti-endotoxin activity in lab animals: R. W. Pfirrmann, G. B. Leslie, ibid. 46, 97 (1979). Mechanism of action: E. Myers et al., ibid. 48, 89 (1980). HPLC determn of metabolites in plasma: A. D. Woolfson et al., Int. J. Pharm. 49, 135 (1989). Pharmacokinetics: C. Steinbach-Lebbin et al., Arzneim.-Forsch. 32, 1542 (1982). Metabolism in humans: B. I. Knight et al., Br. J. Clin. Pharmacol. 12, 695 (1981). Clinical trials in peritonitis: M. K. Browne et al., Surg. Gynecol. Obstet. 146, 721 (1978); G. Wesch et al., Fortschr. Med. 101, 545 (1983); in wound sepsis: A. K. Halsall et al., Pharmatherapeutica 2, 673 (1981); in pleural infection: A. A. Conlan et al., S. Afr. Med. J. 64, 653 (1983).
Properties: White crystals, mp 154-158°. Sol in water.
Melting point: mp 154-158°
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic).