Home > Name List By 8 > 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3, 8-triazaspiro[4.5]decan-4-one

CAS No 1841-19-6 , 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,
8-triazaspiro[4.5]decan-4-one

  • Name: 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,
    8-triazaspiro[4.5]decan-4-one
  • Synonyms: Spirodiflamine; Fluspirilen; Fluspirilenum [INN-Latin]; Imap;Redeptin; Lopac-F-100; Fluspirileno; Fluspirileno [INN-Spanish];8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,
    8-triazaspiro[4.5]decan-4-one;
  • CAS Registry Number:
  • Transport: 3249
  • Flash Point: 358.3°C
  • Boiling Point: 668.9°Cat760mmHg
  • Density: 1.25g/cm3
  • Refractive index: 1.631
  • Safety Statements: Poison by intramuscular route. Human systemic effects by intravenous route: corrosive to skin. When heated to decomposition it emits very toxic fumes of F− and NOx. See also FLUORIDES.
  • Flash Point: 358.3°C
  • EINECS: 217-418-6
  • Molecular Weight: 475.572746
  • InchiKey: QOYHHIBFXOOADH-UHFFFAOYSA-N
  • InChI: InChI=1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)
    7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,
    8-15,27H,4,7,16-21H2,(H,32,35)
  • Molecular Formula: C29H31F2N3O
  • Molecular Structure:CAS No:1841-19-6 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,<br />8-triazaspiro[4.5]decan-4-one

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References of 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,
8-triazaspiro[4.5]decan-4-one
Title: Fluspirilene
CAS Registry Number: 1841-19-6
CAS Name: 8-[4,4-Bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Manufacturers' Codes: R-6128
Trademarks: Imap (McNeil); Redeptin (SK & F)
Molecular Formula: C29H31F2N3O
Molecular Weight: 475.57
Percent Composition: C 73.24%, H 6.57%, F 7.99%, N 8.84%, O 3.36%
Literature References: Prepn: BE 633914; P. A. J. Janssen, US 3238216 (1963, 1966 both to Janssen). HPLC determn: A. H. Hikal, H. I. Al-Shoura, J. Liq. Chromatogr. 5, 2205 (1982). Metabolism in rat: J. P. P. Heykants, Life Sci. 8, Part I, 1029 (1969). Pharmacology: P. A. J. Janssen et al., Arzneim.-Forsch. 20, 1689 (1970). Calcium channel blocking activity: R. J. Gould et al., Proc. Natl. Acad. Sci. USA 80, 5122 (1983); J. P. Galizzi et al., ibid. 83, 7513 (1986). Clinical trials in schizophrenia: H. Immich et al., Arzneim.-Forsch. 20, 1699 (1970); G. Chouinard et al., J. Clin. Psychopharmacol. 6, 21 (1986).
Properties: White to yellowish amorphous or crystalline solid, mp 187.5-190°. Soly in water: 0.015-0.020 mg/ml. LD50 i.m. in rats: 146 ±14 mg/kg (Janssen).
Melting point: mp 187.5-190°
Toxicity data: LD50 i.m. in rats: 146 ±14 mg/kg (Janssen)
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic.