Home > Name List By 3 > 3-(5,6-dihydrodibenzo[1,2-a:1', 2'-e][7]annulen-11-ylidene)-1-ethyl-2-methylpyrrolidine

CAS No 16378-21-5 , 3-(5,6-dihydrodibenzo[1,2-a:1',
2'-e][7]annulen-11-ylidene)-1-ethyl-2-methylpyrrolidine

  • Name: 3-(5,6-dihydrodibenzo[1,2-a:1',
    2'-e][7]annulen-11-ylidene)-1-ethyl-2-methylpyrrolidine
  • Synonyms: Piroheptine (INN); AC1Q1IWI; 16378-21-5; Piroheptina;3-(5,6-dihydrodibenzo[1,2-a:1',
    2'-e][7]annulen-11-ylidene)-1-ethyl-2-methylpyrrolidine; SureCN34782; Piroheptine [INN]; Piroheptinum [INN-Latin]; Piroheptinum;Trimol;
  • CAS Registry Number:
  • Flash Point: 191.7°C
  • Boiling Point: 434.5°Cat760mmHg
  • Density: 1.068g/cm3
  • Refractive index: 1.596
  • Safety Statements: Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 191.7°C
  • Molecular Weight: 303.4406
  • InchiKey: NKJQZSDCCLDOQH-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H25N/c1-3-23-15-14-19(16(23)2)22-20-10-6-4-8-17(20)12-13-18-
    9-5-7-11-21(18)22/h4-11,16H,3,12-15H2,1-2H3
  • Molecular Formula: C22H25N
  • Molecular Structure:CAS No:16378-21-5 3-(5,6-dihydrodibenzo[1,2-a:1',<br />2'-e][7]annulen-11-ylidene)-1-ethyl-2-methylpyrrolidine

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References of 3-(5,6-dihydrodibenzo[1,2-a:1',
2'-e][7]annulen-11-ylidene)-1-ethyl-2-methylpyrrolidine
Title: Piroheptine
CAS Registry Number: 16378-21-5
CAS Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-ethyl-2-methylpyrrolidine
Molecular Formula: C22H25N
Molecular Weight: 303.44
Percent Composition: C 87.08%, H 8.30%, N 4.62%
Literature References: Prepn: NL 6609280; Y. Deguchi et al., US 3454595 (1967, 1969 both to Fujisawa). Crystal structure: Y. Tokuma et al., Bull. Chem. Soc. Jpn. 44, 2665 (1971). Pharmacological studies: M. Hitomi et al., Arzneim.-Forsch. 22, 953, 961 (1972). In vitro study: T. Ohashi et al., ibid. 966. Metabolism: Y. Tokuma et al., Bull. Chem. Soc. Jpn. 48, 294 (1975). Clinical pharmacology: A. Barbeau, Annu. Rev. Pharmacol. 14, 91 (1974). Toxicity study: M. Hitomi et al., Arzneim.-Forsch. 22, 961 (1972).
Properties: Liquid, bp4 167°. uv max (95% ethanol): 240 nm (e 12100).
Boiling point: bp4 167°
Absorption maximum: uv max (95% ethanol): 240 nm (e 12100)
 
Derivative Type: Hydrochloride
CAS Registry Number: 16378-22-6
Trademarks: Trimol (Fujisawa)
Molecular Formula: C22H25N.HCl
Molecular Weight: 339.90
Percent Composition: C 77.74%, H 7.71%, N 4.12%, Cl 10.43%
Properties: Crystals, mp 250-253°. LD50 in male mice, rats (mg/kg): 153, 600 orally; 19, 17 i.v.; 95, 110 i.p.; 109, 330 s.c. (Hitomi).
Melting point: mp 250-253°
Toxicity data: LD50 in male mice, rats (mg/kg): 153, 600 orally; 19, 17 i.v.; 95, 110 i.p.; 109, 330 s.c. (Hitomi)
 
Therap-Cat: Antiparkinsonian.
Keywords: Antiparkinsonian.