Home > Name List By 3 > 3-(5,6-dihydrodibenzo[2,1-b:2', 1'-f][7]annulen-11-ylidene)-N-methylpropan-1-amine

CAS No 72-69-5 , 3-(5,6-dihydrodibenzo[2,1-b:2',
1'-f][7]annulen-11-ylidene)-N-methylpropan-1-amine

  • Name: 3-(5,6-dihydrodibenzo[2,1-b:2',
    1'-f][7]annulen-11-ylidene)-N-methylpropan-1-amine
  • Synonyms: Ateben; Noramitriptyline; Psychostyl;Sensaval;3-(5,6-dihydrodibenzo[2,1-b:2',
    1'-f][7]annulen-11-ylidene)-N-methylpropan-1-amine; Lumbeck; Desitriptilina; Avantyl; Noritren; Nortryptiline;
  • CAS Registry Number:
  • Melting Point: 263.377
  • Density: 1.084 g/cm3
  • Refractive index: 1.633
  • Safety Statements: Poison by ingestion, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
  • EINECS: 200-788-8
  • Molecular Weight: 263.37674
  • InchiKey: PHVGLTMQBUFIQQ-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18
    (16)19/h2-5,7-11,20H,6,12-14H2,1H3
  • Molecular Formula: C19H21N
  • Molecular Structure:CAS No:72-69-5 3-(5,6-dihydrodibenzo[2,1-b:2',<br />1'-f][7]annulen-11-ylidene)-N-methylpropan-1-amine

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References of 3-(5,6-dihydrodibenzo[2,1-b:2',
1'-f][7]annulen-11-ylidene)-N-methylpropan-1-amine
Title: Nortriptyline
CAS Registry Number: 72-69-5
CAS Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
Synonyms: 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-D5,g-propylamine; 5-(a-methylaminopropylidene)dibenzo[a,d]cyclohepta[1,4]diene; 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methylpropylamine; 10,11-dihydro-5-(3-methylaminopropylidene)-5H-dibenzo[a,d][1,4]cycloheptene; desitriptilina; desmethylamitriptyline
Trademarks: Avantyl; Aventyl (Lilly); Noritren (Lundbeck); Ateben (Chem-Sintyal); Psychostyl; Sensaval
Molecular Formula: C19H21N
Molecular Weight: 263.38
Percent Composition: C 86.64%, H 8.04%, N 5.32%
Literature References: Tricyclic antidepressant. Prepn: Hoffsommer et al., J. Org. Chem. 27, 4134 (1962); NL 6408512; E. I. Engelhardt, US 3922305 (1965, 1975 both to Merck & Co.). Alternative process: N. L. Wendler, US 3442949 (1969 to Merck & Co.). GC determn in plasma: J. E. Burch, J. Chromatogr. 308, 165 (1984). Determn in plasma or serum by radioimmunoassay: J. F. Sayegh, Neurochem. Res. 11, 193 (1986). Pharmacokinetics: E. H. Rubin et al., J. Clin. Psychiatry 46, 418 (1985). Clinical trial in post-stroke depression: J. R. Lipsey et al., Lancet 1, 297 (1984). Anticholinergic effect and clinical efficacy in urinary dysfunction: I. Nissenkorn et al., Eur. Urol. 12, 109 (1986). Comprehensive description: J. L. Hale, Anal. Profiles Drug Subs. 1, 233-247 (1972).
 
Derivative Type: Hydrochloride
CAS Registry Number: 894-71-3
Trademarks: Acetexa (Lilly); Allegron (Dista); Nortrilen (Troponwerke); Norzepine; Pamelor (Novartis); Sensival; Vividyl (Lilly)
Molecular Formula: C19H21N.HCl
Molecular Weight: 299.84
Percent Composition: C 76.11%, H 7.40%, N 4.67%, Cl 11.82%
Properties: Crystals from ether + ethanol, mp 213-215°. Sol in ethanol, water, chloroform. Practically insol in ether, acetone, benzene. uv max (methanol): 240 nm (e 13900).
Melting point: mp 213-215°
Absorption maximum: uv max (methanol): 240 nm (e 13900)
 
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Tricyclics.