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CAS No 77-67-8 , 3-ethyl-3-methylpyrrolidine-2,5-dione

  • Name: 3-ethyl-3-methylpyrrolidine-2,5-dione
  • Synonyms: Emeside; Suxinutin; Ethymal; Ethosuccinimide;3-ethyl-3-methylpyrrolidine-2,5-dione; Suxilep; Ethosuccimide;Zarontin; Petnidan; Etosuximida;
  • CAS Registry Number:
  • Water Solubility: ethanol: 100 mg/mL
  • Safety Statements: 36
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 201-048-7
  • Molecular Weight: 141.16774
  • InchiKey: HAPOVYFOVVWLRS-UHFFFAOYSA-N
  • InChI: InChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
  • Risk Statements: 22
  • Molecular Formula: C7H11NO2
  • Molecular Structure:CAS No:77-67-8 3-ethyl-3-methylpyrrolidine-2,5-dione

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References of 3-ethyl-3-methylpyrrolidine-2,5-dione
Title: Ethosuximide
CAS Registry Number: 77-67-8
CAS Name: 3-Ethyl-3-methyl-2,5-pyrrolidinedione
Synonyms: 2-ethyl-2-methylsuccinimide; a-ethyl-a-methylsuccinimide; 3-methyl-3-ethylpyrrolidine-2,5-dione
Trademarks: Atysmal (Schaefer); Capitus (Berk); Emeside (L.A.B.); Epileo Petitmal (Eisai); Ethymal; Mesentol; Pemal (Benzon); Peptinimid (Iromedica); Petinimid; Petnidan (Desitin); Pyknolepsinum (Rhein-Pharma); Simatin (Geistlich); Succimal (Clin-Comar-Byla); Suxilep; Suximal; Suxinutin (Parke-Davis); Zarontin (Parke-Davis)
Molecular Formula: C7H11NO2
Molecular Weight: 141.17
Percent Composition: C 59.56%, H 7.85%, N 9.92%, O 22.67%
Literature References: Prepn: Sircar, J. Chem. Soc. 1927, 1252. Acute toxicity data: H. Najer et al., Bull. Soc. Chim. Fr. 3, 1119 (1966). Comparative clinical trial with valproic acid in epilepsy: S. Sato et al., Neurology 32, 157 (1982). Brief review: S. J. Wallace, Neurol. Clin. 4, 601 (1986).
Properties: Crystals from acetone + ether, mp 64-65°. Freely sol in water. LD50 in mice (g/kg): 1.65 i.p.; 1.75 orally (Najer).
Melting point: mp 64-65°
Toxicity data: LD50 in mice (g/kg): 1.65 i.p.; 1.75 orally (Najer)
Therap-Cat: Anticonvulsant.
Keywords: Anticonvulsant.