Home > Name List By 2 > 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5, 7-dihydropyrrolizin-3-yl]acetic acid

CAS No 156897-06-2 , 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,
7-dihydropyrrolizin-3-yl]acetic acid

  • Name: 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,
    7-dihydropyrrolizin-3-yl]acetic acid
  • Synonyms: ML-3000; ML 3000; CHEMBL300982; BRN 6823674; Licofelone [INN]; C23H22ClNO2;2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,
    7-dihydropyrrolizin-3-yl]acetic acid; AC1L320X; UNII-P5T6BYS22Y; 156897-06-2;
  • CAS Registry Number:
  • Density: 1.23
  • Refractive index: 1.626
  • Molecular Weight: 379.87928
  • InchiKey: UAWXGRJVZSAUSZ-UHFFFAOYSA-N
  • InChI: InChI=1S/C23H22ClNO2/c1-23(2)13-19-22(15-6-4-3-5-7-15)21(16-8-10-17(24)
    11-9-16)18(12-20(26)27)25(19)14-23/h3-11H,12-14H2,1-2H3,(H,26,27)
  • Molecular Formula: C23H22ClNO2
  • Molecular Structure:CAS No:156897-06-2 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,<br />7-dihydropyrrolizin-3-yl]acetic acid

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References of 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,
7-dihydropyrrolizin-3-yl]acetic acid
Title: Licofelone
CAS Registry Number: 156897-06-2
CAS Name: 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic acid
Manufacturers' Codes: ML-3000
Molecular Formula: C23H22ClNO2
Molecular Weight: 379.88
Percent Composition: C 72.72%, H 5.84%, Cl 9.33%, N 3.69%, O 8.42%
Literature References: Dual inhibitor of cyclooxygenase and 5-lipoxygenase. Prepn: G. Dannhardt et al., EP 397175; eidem, US 5260451 (1990, 1993 both to Merckle); S. A. Laufer et al., J. Med. Chem. 37, 1894 (1994); J. Cossy, D. Belotti, Tetrahedron 55, 5145 (1999). Mechanism of action: S. Tries et al., Inflamm. Res. 51, 135 (2002). Experience in experimental dog osteoarthritis: D. Lajeunesse et al., Ann. Rheum. Dis. 63, 78 (2004). Gastrointestinal safety profile in dogs: M. Moreau et al., J. Vet. Pharmacol. Ther. 28, 81 (2005). Review of clinical development: S. Laufer, Inflammopharmacology 9, 101-112 (2001); J. M. Alvaro-Gracia, Rheumatology 43, Suppl. 1, i21-i25 (2004).
Properties: Slightly yellowish solid, mp 162-163°.
Melting point: mp 162-163°
Therap-Cat: Anti-inflammatory.
Therap-Cat-Vet: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal).