Home > Name List By 2 > 2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino] acetic acid

CAS No 82964-04-3 , 2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]
acetic acid

  • Name: 2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]
    acetic acid
  • Synonyms: Alredase;2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]
    acetic acid; CHEBI:48549; AY-27773; 82964-04-3; Tolrestatum [Latin]; NCGC00183862-01; AY-27,773; Tolrestatum;
  • CAS Registry Number:
  • Flash Point: 255°C
  • Boiling Point: 498.1°C at 760 mmHg
  • Density: 1.399g/cm3
  • Refractive index: 1.601
  • Flash Point: 255°C
  • Molecular Weight: 357.34747
  • InchiKey: LUBHDINQXIHVLS-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-
    2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22)
  • Molecular Formula: C16H14F3NO3S
  • Molecular Structure:CAS No:82964-04-3 2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]<br />acetic acid

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References of 2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]
acetic acid
Title: Tolrestat
CAS Registry Number: 82964-04-3
CAS Name: N-[[6-Methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglycine
Synonyms: tolrestatin
Manufacturers' Codes: AY-27773
Trademarks: Alredase (Am. Home); Lorestat (Recordati)
Molecular Formula: C16H14F3NO3S
Molecular Weight: 357.35
Percent Composition: C 53.78%, H 3.95%, F 15.95%, N 3.92%, O 13.43%, S 8.97%
Literature References: Orally active aldose reductase inhibitor. Prepn and pharmacology: K. Sestanj et al., EP 59596 (1982 to Ayerst); eidem, J. Med. Chem. 27, 255 (1984). Prevention of cataracts in galactosemic rats: N. Simard-Duquesne et al., Proc. Soc. Exp. Biol. Med. 178, 599 (1985). Kinetics and metabolism in man: D. R. Hicks et al., Clin. Pharmacol. Ther. 36, 493 (1984). Ultraviolet and HPLC determn in serum: D. R. Hicks, M. Kraml, Ther. Drug Monit. 6, 328 (1984). Effect on erythrocyte sorbitol levels in diabetic patients: P. Raskin et al., Clin. Pharmacol. Ther. 38, 625 (1985).
Properties: mp 164-165°.
Melting point: mp 164-165°
 
Derivative Type: Methyl ester
Molecular Formula: C17H16F3NO3S
Molecular Weight: 371.37
Percent Composition: C 54.98%, H 4.34%, F 15.35%, N 3.77%, O 12.92%, S 8.63%
Properties: mp 109-110°.
Melting point: mp 109-110°
 
Therap-Cat: Treatment of diabetic neuropathy.
Keywords: Aldose Reductase Inhibitor.