Home > Name List By 2 > 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3, 4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid

CAS No 156053-89-3 , 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,
4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid

  • Name: 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,
    4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid
  • Synonyms: Adl 8-2698; 156053-89-3;2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,
    4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid; AC1NUQN6; LY246736; LY 246736; Alvimopan anhydrous;Entereg; trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine;
  • CAS Registry Number:
  • Melting Point: 210-213 deg C
  • Flash Point: 367.5°C
  • Boiling Point: 684.1°Cat760mmHg
  • Density: g/cm3
  • Flash Point: 367.5°C
  • Molecular Weight: 424.53258
  • InchiKey: UPNUIXSCZBYVBB-JVFUWBCBSA-N
  • InChI: InChI=1S/C25H32N2O4/c1-18-16-27(12-11-25(18,
    2)21-9-6-10-22(28)14-21)17-20(24(31)26-15-23(29)30)13-19-7-4-3-5-8-19/
    h3-10,14,18,20,28H,11-13,15-17H2,1-2H3,(H,26,31)(H,29,30)/t18-,20-,
    25+/m0/s1
  • Molecular Formula: C25H32N2O4
  • Molecular Structure:CAS No:156053-89-3 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,<br />4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid

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156053-89-3 Glycine,N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-

  • China Hangzhou Sage Chemical Co., Ltd. [Manufacturer]
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  • Address: RM501 Tower A, New Youth Plaza, NO.8 Jia Shan Road, Hangzhou, Zhejiang 310014, null,ZhejiangChina
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156053-89-3 ALVIMOPAN

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170098-38-1; 156053-89-3 Alvimopan

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References of 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,
4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid
Title: Alvimopan
CAS Registry Number: 156053-89-3
CAS Name: N-[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]glycine
Synonyms: [[2(S)-[[4(R)-(3-hydroxyphenyl)-3(R),4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]amino]acetic acid
Manufacturers' Codes: ADL-8-2698; LY-246736
Trademarks: Entereg (Adolor)
Molecular Formula: C25H32N2O4
Molecular Weight: 424.53
Percent Composition: C 70.73%, H 7.60%, N 6.60%, O 15.07%
Literature References: Peripheral mu-opioid receptor antagonist. Prepn: B. E. Cantrell et al., EP 506478; eidem, US 5250542 (1992, 1993 both to Lilly); D. M. Zimmerman et al., J. Med. Chem. 37, 2262 (1994). Improved synthesis: J. A. Werner et al., J. Org. Chem. 61, 587 (1996). Clinical pharmacology: S. S. Liu et al., Clin. Pharmacol. Ther. 68, 66 (2000). Clinical trial in postoperative ileus: A. Taguchi et al., N. Engl. J. Med. 345, 935 (2001); E. R. Viscusi et al., Surg. Endosc. 20, 64 (2006). Review of clinical experience: W. K. Schmidt, Am. J. Surg. 182, Suppl., 27S-38S (2001); and pharmacology: P. Neary, C. P. Delaney, Expert Opin. Invest. Drugs 14, 479-488 (2005).
 
Derivative Type: Dihydrate
CAS Registry Number: 170098-38-1
Properties: Crystals, mp 210-213°. [a]D25 +51.8° (c = 1.0 in DMSO).
Melting point: mp 210-213°
Optical Rotation: [a]D25 +51.8° (c = 1.0 in DMSO)
 
Therap-Cat: Gastroprokinetic.
Keywords: Gastroprokinetic.