Home > Name List By 1 > 1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[(2- acetamido-3-naphthalen-2-ylpropanoyl)amino]-3-(4-chlorop...

CAS No 124904-93-4 , 1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[(2-
acetamido-3-naphthalen-2-ylpropanoyl)amino]-3-(4-chlorophenyl)propanoyl]
amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-
hydroxyphenyl)propanoyl]amino]-6-[bis(ethylamino)methylideneamino]
hexanoyl]amino]-4-methylpentanoyl]amino]-6-[bis(ethylamino)
methylideneamino]hexanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-
2-carboxamide

  • Name: 1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[(2-
    acetamido-3-naphthalen-2-ylpropanoyl)amino]-3-(4-chlorophenyl)propanoyl]
    amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-
    hydroxyphenyl)propanoyl]amino]-6-[bis(ethylamino)methylideneamino]
    hexanoyl]amino]-4-methylpentanoyl]amino]-6-[bis(ethylamino)
    methylideneamino]hexanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-
    2-carboxamide
  • Synonyms: Ganirelixum [INN-Latin]; Ganirelix [INN:BAN];1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[(2-
    acetamido-3-naphthalen-2-ylpropanoyl)amino]-3-(4-chlorophenyl)propanoyl]
    amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-
    hydroxyphenyl)propanoyl]amino]-6-[bis(ethylamino)methylideneamino]
    hexanoyl]amino]-4-methylpentanoyl]amino]-6-[bis(ethylamino)
    methylideneamino]hexanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-
    2-carboxamide; 123246-29-7; Ganirelixum; UNII-IX503L9WN0; Ganirelix acetate;Orgalutran;
  • CAS Registry Number:
  • Density: 1.31 g/cm3
  • Molecular Weight: 1570.31902
  • InchiKey: GJNXBNATEDXMAK-RXXWGPEVSA-N
  • InChI: InChI=1S/C80H113ClN18O13/c1-9-84-79(85-10-2)88-38-17-15-24-60(70(104)94-
    62(41-49(5)6)71(105)93-61(25-16-18-39-89-80(86-11-3)87-12-4)78(112)99-
    40-20-26-68(99)77(111)90-50(7)69(82)103)92-73(107)64(44-53-30-35-59(102)
    36-31-53)97-76(110)67(48-100)98-75(109)66(46-55-21-19-37-83-47-55)96-74
    (108)65(43-52-28-33-58(81)34-29-52)95-72(106)63(91-51(8)101)45-54-27-32-
    56-22-13-14-23-57(56)42-54/h13-14,19,21-23,27-37,42,47,49-50,60-68,100,
    102H,9-12,15-18,20,24-26,38-41,43-46,48H2,1-8H3,(H2,82,103)(H,90,111)(H,
    91,101)(H,92,107)(H,93,105)(H,94,104)(H,95,106)(H,96,108)(H,97,110)(H,
    98,109)(H2,84,85,88)(H2,86,87,89)/t50-,60-,61+,62+,63?,64-,65+,66+,67-,
    68?/m1/s1
  • Molecular Formula: C80H113ClN18O13
  • Molecular Structure:CAS No:124904-93-4 1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[(2-<br />acetamido-3-naphthalen-2-ylpropanoyl)amino]-3-(4-chlorophenyl)propanoyl]<br />amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-<br />hydroxyphenyl)propanoyl]amino]-6-[bis(ethylamino)methylideneamino]<br />hexanoyl]amino]-4-methylpentanoyl]amino]-6-[bis(ethylamino)<br />methylideneamino]hexanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-<br />2-carboxamide

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1/1
References of 1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[(2-
acetamido-3-naphthalen-2-ylpropanoyl)amino]-3-(4-chlorophenyl)propanoyl]
amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-
hydroxyphenyl)propanoyl]amino]-6-[bis(ethylamino)methylideneamino]
hexanoyl]amino]-4-methylpentanoyl]amino]-6-[bis(ethylamino)
methylideneamino]hexanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-
2-carboxamide
Title: Ganirelix
CAS Registry Number: 124904-93-4
CAS Name: N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N6-[bis(ethylamino)methylene]-D-lysyl-L-leucyl-N6-[bis(ethylamino)methylene]-L-lysyl-L-prolyl-D-alaninamide
Synonyms: [N-Ac-D-Nal(2)1-D-pCl-Phe2-D-Pal(3)3-D-hArg(Et2)6-hArg(Et2)8-D-Ala10]GnRH
Molecular Formula: C80H113ClN18O13
Molecular Weight: 1570.32
Percent Composition: C 61.19%, H 7.25%, Cl 2.26%, N 16.06%, O 13.25%
Literature References: Decapeptide LH-RH antagonist. Prepn and structure-activity studies: J. J. Nestor, Jr. et al. in Peptides 1988: Proc. 20th Eur. Peptide Symp., G. Jung, E. Bayer, Eds. (Walter de Gruyter, Berlin, 1989) pp 592-594; eidem, J. Med. Chem. 35, 3942 (1992). Improved synthesis: H. B. Arzeno et al., Int. J. Pept. Protein Res. 41, 342 (1993). Degradation in aq soln: R. G. Strickley et al., Pharm. Res. 7, 530 (1990). Clinical pharmacology and pharmacokinetics: J. Rabinovici et al., J. Clin. Endocrinol. Metab. 75, 1220 (1992). Clinical trial in assisted fertilization: P. Devroey et al., Hum. Reprod. 13, 3023 (1998).
 
Derivative Type: Acetate
CAS Registry Number: 129311-55-3
Manufacturers' Codes: Org-37462; RS-26306
Trademarks: Antagon (Organon); Orgalutran (Organon)
Molecular Formula: C80H113ClN18O13.2C2H4O2
Molecular Weight: 1690.42
Percent Composition: C 59.68%, H 7.21%, Cl 2.10%, N 14.91%, O 16.09%
Properties: pKa: 4.2 (3-pyridinylalanine); 9.8 (tyrosine). Sol in water.
pKa: pKa: 4.2 (3-pyridinylalanine); 9.8 (tyrosine)
 
Therap-Cat: In treatment of infertility.
Keywords: LH-RH Antagonist.