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CAS No 14759-06-9 , 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfonylphenothiazine

  • Name: 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfonylphenothiazine
  • Synonyms: Sulforidazine [INN:DCF]; TPN 12; Inofal;10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfonylphenothiazine; Psychoson; TPN-12; sulphoridazine; Thioridazine 2-Sulfone; Solforidazina [DCIT];Imagotan;
  • CAS Registry Number:
  • Flash Point: 310.1°C
  • Boiling Point: 589.1°Cat760mmHg
  • Density: 1.221g/cm3
  • Refractive index: 1.605
  • Flash Point: 310.1°C
  • EINECS: 238-818-7
  • Molecular Weight: 402.57334
  • InchiKey: FLGCRGJDQJIJAW-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H26N2O2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)26-
    21-11-10-17(15-19(21)23)27(2,24)25/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
  • Molecular Formula: C21H26N2O2S2
  • Molecular Structure:CAS No:14759-06-9 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfonylphenothiazine

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References of 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfonylphenothiazine
Title: Sulforidazine
CAS Registry Number: 14759-06-9
CAS Name: 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylsulfonyl)-10H-phenothiazine
Synonyms: 3-(methylsulfonyl)-10-[2-(1-methyl-2-piperidyl)ethyl]phenothiazine; thioridazine-2-sulfone
Manufacturers' Codes: TPN-12
Trademarks: Imagotan (Sandoz); Inofal (Sandoz)
Molecular Formula: C21H26N2O2S2
Molecular Weight: 402.57
Percent Composition: C 62.65%, H 6.51%, N 6.96%, O 7.95%, S 15.93%
Literature References: Dopamine receptor blocker; metabolite of thioridazine and mesoridazine, q.q.v. Prepn: Renz et al., FR 1363683 and FR 1459476 (1964, 1966, both to Sandoz). Pharmacology: Maruyama et al., C.A. 68, 20799z (1968). Effects on dopaminergic function in comparison with mesoridazine and thioridazine: D. M. Niedzwiecki et al., J. Pharmacol. Exp. Ther. 228, 636 (1984); C. D. Kilts et al., ibid. 231, 334 (1984). Clinical evaluation as antipsychotic: R. Axelsson, Curr. Ther. Res. 21, 587 (1977). HPLC determn in plasma: D. A. Ganes, K. K. Midha, J. Chromatogr. 423, 227 (1987).
Properties: Crystals from acetone, mp 121-123°.
Melting point: mp 121-123°
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Phenothiazines.