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CAS No 64-65-3 , 4-ethyl-4-methylpiperidine-2,6-dione

  • Name: 4-ethyl-4-methylpiperidine-2,6-dione
  • Synonyms: Megimide;4-ethyl-4-methylpiperidine-2,6-dione; Zentraleptin; Agipnon;3-Ethyl-3-methylglutarimide; Bemegrid; 64-65-3; Ahypnon; Antibarbi; Methetharimide;
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 2
  • Melting Point: 126-127 °C(lit.)
  • Flash Point: 125.8°C
  • Boiling Point: 282°C at 760 mmHg
  • Density: 1.024g/cm3
  • Refractive index: 1.448
  • Safety Statements: Poison by ingestion, intravenous, intraperitoneal, intramuscular, subcutaneous, and parenteral routes. Human systemic effects by ingestion: wakefulness, hallucinations, distorted perceptions, toxic psychosis. An analeptic, central nervous system stimulant; used to counteract barbiturate poisoning. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: T
  • Flash Point: 125.8°C
  • EINECS: 200-588-0
  • Molecular Weight: 155.19432
  • InchiKey: ORRZGUBHBVWWOP-UHFFFAOYSA-N
  • InChI: InChI=1S/C8H13NO2/c1-3-8(2)4-6(10)9-7(11)5-8/h3-5H2,1-2H3,(H,9,10,11)
  • Risk Statements: 23/24/25
  • Molecular Formula: C8H13NO2
  • Molecular Structure:CAS No:64-65-3 4-ethyl-4-methylpiperidine-2,6-dione

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References of 4-ethyl-4-methylpiperidine-2,6-dione
Title: Bemegride
CAS Registry Number: 64-65-3
CAS Name: 4-Ethyl-4-methyl-2,6-piperidinedione
Synonyms: 3-ethyl-3-methylglutarimide; 4-ethyl-4-methyl-2,6-dioxopiperidine; 2,6-dioxo-4-methyl-4-ethylpiperidine; methetharimide; b,b-methylethylglutarimide
Manufacturers' Codes: NP-13
Trademarks: Eukraton (Nordmark); Megimide (Inibsa)
Molecular Formula: C8H13NO2
Molecular Weight: 155.19
Percent Composition: C 61.91%, H 8.44%, N 9.03%, O 20.62%
Literature References: Prepn: Thole, Thorpe, J. Chem. Soc. 99, 439 (1911); Sircar, ibid. 1937, 602, 604; Benica, Wilson, J. Am. Pharm. Assoc. Sci. Ed. 39, 451 (1950); Lukes, Ferles, Chem. Listy 49, 510 (1955), C.A. 49, 10290 (1955). Pharmacology: Delay et al., Presse Med. 64, 1525 (1956); Oberdorf, Meyer, Arch. Exp. Pathol. Pharmakol. 238, 128 (1960); Kretzschmar et al., Arch. Int. Pharmacodyn. Ther. 174, 318 (1968). Metabolism: Nicholls, Nature 185, 927 (1960). Toxicity study: F. Hahn, A. Oberdorf, Arch. Int. Pharmacodyn. Ther. 135, 9 (1962). Reduction of barbiturate anesthesia in mice: V. K. Patel et al., Psychopharmacology 71, 21 (1980). Postsynaptic effects: P. W. Gage, P. Sah, Br. J. Pharmacol. 75, 493 (1982).
Properties: Platelets from water or from acetone + ether, mp 127°. Sublimes at 100° and 2 mm press. Sol in water, acetone. LD50 in male mice (mg/kg): 20.1 ±1.41 i.v., 43.0 ±1.8 s.c.; LD50 in male rats (mg/kg): 16.3 ±1.24 i.v., 23.5 ±1.67 i.p (Hahn, Oberdorf).
Melting point: mp 127°
Toxicity data: LD50 in male mice (mg/kg): 20.1 ±1.41 i.v., 43.0 ±1.8 s.c.; LD50 in male rats (mg/kg): 16.3 ±1.24 i.v., 23.5 ±1.67 i.p (Hahn, Oberdorf)
Therap-Cat: CNS stimulant. Antidote (barbiturate poisoning).
Therap-Cat-Vet: CNS stimulant. Antidote (barbiturate poisoning).
Keywords: CNS Stimulant; Respiratory Stimulant.