References of 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]
methyl]phenyl]benzoic acid
Title: Telmisartan
CAS Registry Number: 144701-48-4
CAS Name: 4￠-[(1,4￠-Dimethyl-2￠-propyl[2,6￠-bi-1
H-benzimidazol]-1￠-yl)methyl][1,1￠-biphenyl]-2-carboxylic acid
Synonyms: 4￠-[[4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid
Manufacturers' Codes: BIBR 277
Trademarks: Kinzalmono (Bayer); Micardis (Boehringer, Ing.); Pritor (GSK)
Molecular Formula: C33H30N4O2
Molecular Weight: 514.62
Percent Composition: C 77.02%, H 5.88%, N 10.89%, O 6.22%
Literature References: Angiotensin II receptor antagonist. Prepn: N. Hauel
et al., EP 502314 (1992 to Thomae),
C.A. 117, 251352 (1992); U. J. Ries
et al., J. Med. Chem. 36, 4040 (1993). Pharmacology: W. Wienen
et al., Br. J. Pharmacol. 110, 245 (1993). Binding study: W. Wienen, M. Entzeroth,
J. Hypertens. 12, 119 (1994). Clinical pharmacology, pharmacokinetics: J. M. Neutel, D. H. G. Smith,
Adv. Ther. 15, 206 (1998). Clinical trial in hypertension: D. H. G. Smith
et al., ibid. 229. Review of pharmacology and clinical efficacy: K. J. McClellan, A. Markham,
Drugs 56, 1039-1044 (1998).
Properties: White solid, mp 261-263°. Practically insol in water (pH 3-9). Sparingly sol in strong acid (except insol in hydrochloric acid); sol in strong base.
Melting point: mp 261-263°
Therap-Cat: Antihypertensive.
Keywords: Angiotensin II Receptor Antagonist; Antihypertensive.
![CAS No:144701-48-4 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]<br />methyl]phenyl]benzoic acid](/structure/cas-144/144701-48-4.png)
