Home > Name List By 2 > 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl] methyl]phenyl]benzoic acid

CAS No 144701-48-4 , 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]
methyl]phenyl]benzoic acid

  • Name: 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]
    methyl]phenyl]benzoic acid
  • Synonyms: BIBR 277; Micardis HCT;Micardis; Kinzalmono; BIBR-277; BIBR 277SE; Pritor; 144701-48-4;2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]
    methyl]phenyl]benzoic acid; CHEBI:9434;
  • CAS Registry Number:
  • Flash Point: 420.6°C
  • Boiling Point: 771.9°Cat760mmHg
  • Density: 1.24g/cm3
  • Refractive index: 1.624
  • Safety Statements: 22-24/25-36-26
  • Hazard Symbols: Xi: Irritant;
  • Flash Point: 420.6°C
  • Molecular Weight: 514.6169
  • InchiKey: RMMXLENWKUUMAY-UHFFFAOYSA-N
  • InChI: InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)
    36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)
    39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
  • Risk Statements: S22;S24/25
  • Molecular Formula: C33H30N4O2
  • Molecular Structure:CAS No:144701-48-4 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]<br />methyl]phenyl]benzoic acid

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References of 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]
methyl]phenyl]benzoic acid
Title: Telmisartan
CAS Registry Number: 144701-48-4
CAS Name: 4￠-[(1,4￠-Dimethyl-2￠-propyl[2,6￠-bi-1H-benzimidazol]-1￠-yl)methyl][1,1￠-biphenyl]-2-carboxylic acid
Synonyms: 4￠-[[4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid
Manufacturers' Codes: BIBR 277
Trademarks: Kinzalmono (Bayer); Micardis (Boehringer, Ing.); Pritor (GSK)
Molecular Formula: C33H30N4O2
Molecular Weight: 514.62
Percent Composition: C 77.02%, H 5.88%, N 10.89%, O 6.22%
Literature References: Angiotensin II receptor antagonist. Prepn: N. Hauel et al., EP 502314 (1992 to Thomae), C.A. 117, 251352 (1992); U. J. Ries et al., J. Med. Chem. 36, 4040 (1993). Pharmacology: W. Wienen et al., Br. J. Pharmacol. 110, 245 (1993). Binding study: W. Wienen, M. Entzeroth, J. Hypertens. 12, 119 (1994). Clinical pharmacology, pharmacokinetics: J. M. Neutel, D. H. G. Smith, Adv. Ther. 15, 206 (1998). Clinical trial in hypertension: D. H. G. Smith et al., ibid. 229. Review of pharmacology and clinical efficacy: K. J. McClellan, A. Markham, Drugs 56, 1039-1044 (1998).
Properties: White solid, mp 261-263°. Practically insol in water (pH 3-9). Sparingly sol in strong acid (except insol in hydrochloric acid); sol in strong base.
Melting point: mp 261-263°
Therap-Cat: Antihypertensive.
Keywords: Angiotensin II Receptor Antagonist; Antihypertensive.