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CAS No 143-62-4 , Card-20(22)-enolide,3,14-dihydroxy-, (3b,5b)-

  • Name: Card-20(22)-enolide,3,14-dihydroxy-, (3b,5b)-
  • Synonyms: D20:22-3,14,21-Trihydroxynorcholenicacid lactone; NSC 407806;Card-20(22)-enolide,3,14-dihydroxy-, (3b,5b)-; Cerberigenin; Digitoxigenin;5b-Card-20(22)-enolide, 3b,14-dihydroxy- (6CI,7CI,8CI);(+)-Digitoxigenin;
  • CAS Registry Number:
  • Transport: UN 3462 6.1/PG 2
  • Melting Point: 253-255 °C (dec.)(lit.)
  • Flash Point: 188.1°C
  • Boiling Point: 549.3°C at 760 mmHg
  • Density: 1.231g/cm3
  • Refractive index: 1.59
  • Safety Statements: Poison by ingestion, subcutaneous, intravenous, and parenteral routes. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Hazard Symbols: T
  • Flash Point: 188.1°C
  • EINECS: 205-603-4
  • Molecular Weight: 374.57
  • InChI: InChI=1/C23H34O4/c1-21-8-5-16(24)12-15(21)3-4-19-18(21)6-9-22(2)17(7-10-23(19,22)26)14-11-20(25)27-13-14/h11,15-19,24,26H,3-10,12-13H2,1-2H3/t15-,16+,17-,18+,19-,21+,22-,23+/m1/s1
  • Risk Statements: 25
  • Molecular Formula: C23H34 O4
  • Molecular Structure:CAS No:143-62-4 Card-20(22)-enolide,3,14-dihydroxy-, (3b,5b)-
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143-62-4 DIGITOXIGENIN

  • Germany ABCR GmbH & Co KG [Manufacturer]
  • Tel: +49 721 95061-0
  • Fax: +49 721 95061-80
  • Address: Im Schlehert 10
    76187 Karlsruhe
    Germany null,nullGermany
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143-62-4 DIGITOXIGENIN

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
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    Hong Kong null,nullHong kong
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143-62-4 DIGITOXIGENIN

  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
    Switzerland null,nullSwitzerland
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143-62-4 DIGITOXIGENIN

  • Germany BIOTREND Chemikalien GmbH [Manufacturer]
  • Tel: ++49 (0)2 21 9 49 83 20
  • Fax: ++49 (0)2 21 9 49 83 25
  • Address: BIOTREND Chemikalien GmbH
    Eupener Str. 157
    D - 50933 Cologne
    Germany null,nullGermany
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143-62-4 DIGITOXIGENIN(P)

  • United States ChromaDex Inc. [Manufacturer]
  • Tel: 949-419-0288
  • Fax: 949-419-0294
  • Address: ChromaDex Inc.
    10005 Muirlands Blvd. Suite G - First Floor
    Irvine, CA 92618 null,nullUnited States
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143-62-4 DIGITOXIGENIN

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
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    (N)Nanjing 210009,China null,nullChina
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References of Card-20(22)-enolide,3,14-dihydroxy-, (3b,5b)-
Title: Digitoxigenin
CAS Registry Number: 143-62-4
CAS Name: (3b,5b)-3,14-Dihydroxycard-20(22)-enolide
Synonyms: D20:22-3,14,21-trihydroxynorcholenic acid lactone; cerberigenin; echujetin; evonogenin
Trademarks: Thevetigenin
Molecular Formula: C23H34O4
Molecular Weight: 374.51
Percent Composition: C 73.76%, H 9.15%, O 17.09%
Literature References: The aglycon of digitoxin, thevetin, cerberin, echujin, evomonosid. Prepn by refluxing digitoxin in a mixture of water + alcohol + HCl: Cloetta, Arch. Exp. Pathol. Pharmakol. 88, 113 (1920); Stoll, Kreiss, Helv. Chim. Acta 17, 592 (1934). Structure: Jacobs, Hoffmann, J. Biol. Chem. 67, 333 (1926); Jacobs, Gustus, ibid. 78, 573; 79, 533 (1928); 82, 402 (1929); Jacobs, Elderfield, ibid. 108, 497 (1935); Elderfield, Chem. Rev. 17, 187 (1935). Stereochemistry: Meyer, Helv. Chim. Acta 30, 1976 (1947). Synthesis: Danieli et al., Tetrahedron 22, 3189 (1966); W. Fritsch et al., Ann. 1974, 621; S. F. Donovan et al., Tetrahedron Lett. 1979, 3287; R. Marinibettolo et al., Can. J. Chem. 59, 1403 (1981); T. Milkova et al., Tetrahedron Lett. 23, 413 (1982). Biosynthesis from neriifolin, q.v.: A. Cruz et al., J. Org. Chem. 42, 3580 (1977).
Properties: Stout prisms from 40% alc, mp 253°. [a]D17 +19.1° (c = 1.36 in methanol). Sol in alc, chloroform, acetone; slightly sol in ethyl acetate; very sparingly sol in ether, water.
Melting point: mp 253°
Optical Rotation: [a]D17 +19.1° (c = 1.36 in methanol)
 
Derivative Type: 3-Acetyldigitoxigenin
Molecular Formula: C25H36O5
Molecular Weight: 416.55
Percent Composition: C 72.08%, H 8.71%, O 19.20%
Properties: Hexagonal plates from acetone + ether, mp 222-227°. [a]D17 +21.4° (c = 1.02 in chloroform).
Melting point: mp 222-227°
Optical Rotation: [a]D17 +21.4° (c = 1.02 in chloroform)