Home > Name List By m > methyl (1R,15S,17R,18R,19S,20S)-18-methoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3, 11,12,14,15,16,17,18,19,20,21-dodecahydroyohi...

CAS No 131-01-1 , methyl
(1R,15S,17R,18R,19S,20S)-18-methoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,
11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate

  • Name: methyl
    (1R,15S,17R,18R,19S,20S)-18-methoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,
    11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
  • Synonyms: Canescin; Deserpidin; Recanescin; Raunormine; Canescine;Harmonyl;methyl
    (1R,15S,17R,18R,19S,20S)-18-methoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,
    11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate; Recanescine; Raunormin; Desepridine;
  • CAS Registry Number:
  • Density: 1.32 g/cm3
  • Refractive index: 1.625
  • Safety Statements: Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. Questionable human carcinogen producing skin tumors. When heated to decomposition it emits toxic fumes of NOx.
  • EINECS: 205-004-8
  • Molecular Weight: 578.65272
  • InchiKey: CVBMAZKKCSYWQR-WCGOZPBSSA-N
  • InChI: InChI=1S/C32H38N2O8/c1-37-24-12-17(13-25(38-2)29(24)39-3)31(35)42-26-14-
    18-16-34-11-10-20-19-8-6-7-9-22(19)33-28(20)23(34)15-21(18)27(30(26)40-
    4)32(36)41-5/h6-9,12-13,18,21,23,26-27,30,33H,10-11,14-16H2,1-5H3/t18-,
    21+,23-,26-,27+,30+/m1/s1
  • Molecular Formula: C32H38N2O8
  • Molecular Structure:CAS No:131-01-1 methyl<br />(1R,15S,17R,18R,19S,20S)-18-methoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,<br />11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate

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131-01-1 DESERPIDINE

  • DESERPIDINE
  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
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131-01-1 Deserpidine

  • China Trust&We Co., Ltd. [Manufacturer]
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131-01-1 Deserpidine

  • China Taiyuan RHF CO., ltd. [Manufacturers]
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131-01-1 Deserpidine

  • Deserpidine, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
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131-01-1 Deserpidine

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131-01-1 Deserpidine

  • United States Aceto Corporation [Importer/Exporter]
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131-01-1 Deserpidine

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131-01-1 Deserpidine

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131-01-1 Deserpidine

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  • China Beijing Merson pharmaceutical Co., Ltd. null
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References of methyl
(1R,15S,17R,18R,19S,20S)-18-methoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,
11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
Title: Deserpidine
CAS Registry Number: 131-01-1
CAS Name: (3b,16b,17a,18b,20a)-17-Methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-3,20-yohimban-16-carboxylic acid methyl ester
Synonyms: 11-desmethoxyreserpine; canescine; recanescine
Trademarks: Harmonyl (Abbott); Raunormine (Penick)
Molecular Formula: C32H38N2O8
Molecular Weight: 578.65
Percent Composition: C 66.42%, H 6.62%, N 4.84%, O 22.12%
Literature References: Isoln from roots of Rauwolfia canescens L., Apocynaceae: A. Stoll, A. Hofmann, J. Am. Chem. Soc. 77, 820 (1955); M. W. Klohs et al., ibid. 4084; N. Neuss et al., ibid. 4087; H. B. MacPhillamy et al., ibid. 4335; E. Schlittler et al., Experientia 11, 64 (1955); GB 791241 (1958 to Penick); GB 809912; P. R. Ulshafer, US 2982769 (1959, 1961 both to Ciba). Stereochemistry: C. F. Huebner et al., Experientia 11, 303 (1955); P. E. Aldrich et al., J. Am. Chem. Soc. 81, 2481 (1959). Synthesis: L. Bláha et al., Collect. Czech. Chem. Commun. 25, 237 (1960); CA 678216 (1964 to Roussel-UCLAF).
Properties: Exists in three cryst forms from methanol: a-form, mp 228-232°; b-form, mp 230-232°; and g-form, mp 138° and 226-232° with resolidification at 175°. [a]D20 -163° (c = 0.5 in pyridine). pKa 6.68 in 40% methanol. uv max (ethanol): 218, 272, 290 nm (log e 4.79, 4.26, 4.07).
Melting point: mp 228-232°; mp 230-232°; mp 138° and 226-232° with resolidification at 175°
pKa: pKa 6.68 in 40% methanol
Optical Rotation: [a]D20 -163° (c = 0.5 in pyridine)
Absorption maximum: uv max (ethanol): 218, 272, 290 nm (log e 4.79, 4.26, 4.07)
 
Derivative Type: Hydrochloride
CAS Registry Number: 6033-69-8
Molecular Formula: C32H38N2O8.HCl
Molecular Weight: 615.11
Percent Composition: C 62.48%, H 6.39%, N 4.55%, O 20.81%, Cl 5.76%
Properties: Thin rectangular plates from acetone, dec 253-256°.
 
Derivative Type: Nitrate
Molecular Formula: C32H38N2O8.HNO3
Molecular Weight: 641.67
Percent Composition: C 59.90%, H 6.13%, N 6.55%, O 27.43%
Properties: Crystals, dec 254-260°.
 
Derivative Type: Oxalate
CAS Registry Number: 119506-01-3
Molecular Formula: C32H38N2O8.C2H2O4
Molecular Weight: 668.69
Percent Composition: C 61.07%, H 6.03%, N 4.19%, O 28.71%
Properties: Crystals, dec 239-243°.
 
Derivative Type: 10-Methoxydeserpidine
CAS Registry Number: 865-04-3
Synonyms: methoserpidine
Trademarks: Decaserpyl
Molecular Formula: C33H40N2O9
Molecular Weight: 608.68
Percent Composition: C 65.12%, H 6.62%, N 4.60%, O 23.66%
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Reserpine Derivatives.