Home > Name List By 5 > 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4, 3-b]indol-1-one

CAS No 122852-42-0 , 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,
3-b]indol-1-one

  • Name: 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,
    3-b]indol-1-one
  • Synonyms: CHEMBL1110; AC1L1CX0; 122852-42-0; GR68755; Alosetron HCl; CHEBI:253342;5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,
    3-b]indol-1-one; Alosetron (INN); GR 68755X;Lotronex;
  • CAS Registry Number:
  • Melting Point: Solidifies at -28 deg C
  • Density: 1.34 g/cm3
  • Refractive index: 1.706
  • Safety Statements: S26;S36;
  • Hazard Symbols: Xi
  • Molecular Weight: 294.35102
  • InchiKey: JSWZEAMFRNKZNL-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H18N4O/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-
    4-6-14(12)20(15)2/h3-6,10H,7-9H2,1-2H3,(H,18,19)
  • Risk Statements: 36/37/38
  • Molecular Formula: C17H18N4O
  • Molecular Structure:CAS No:122852-42-0 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,<br />3-b]indol-1-one

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References of 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,
3-b]indol-1-one
Title: Alosetron
CAS Registry Number: 122852-42-0
CAS Name: 2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one
Manufacturers' Codes: GR-68755
Molecular Formula: C17H18N4O
Molecular Weight: 294.35
Percent Composition: C 69.37%, H 6.16%, N 19.03%, O 5.44%
Literature References: Serotonin 5HT3-receptor antagonist. Prepn: I. H. Coates et al., EP 306323; eidem, US 5360800 (1989, 1994 both to Glaxo); of isotopically labelled compd: S. R. Prakash et al., J. Labelled Compd. Radiopharm. 36, 993 (1995). HPLC determn in plasma: T. L. Lloyd et al., J. Chromatogr. B 678, 261 (1996). Review of clinical pharmacology: M. D. Gunput, Aliment. Pharmacol. Ther. 13, Suppl. 2, 70-76 (1999); of clinical studies: A. W. Mangel, A. R. Northcutt, ibid. 77-82. Clinical trial in irritable bowel syndrome: M. Camilleri et al., Lancet 355, 1035 (2000).
 
Derivative Type: Hydrochloride
CAS Registry Number: 122852-69-1
Manufacturers' Codes: GR-68755C
Trademarks: Lotronex (GSK)
Molecular Formula: C17H18N4O.HCl
Molecular Weight: 330.81
Percent Composition: C 61.72%, H 5.79%, N 16.94%, O 4.84%, Cl 10.72%
Properties: mp 288-291°.
Melting point: mp 288-291°
 
Therap-Cat: In treatment of irritable bowel syndrome.
Keywords: Serotonin Receptor Antagonist.