Home > Name List By other > (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-1,4,7,10,12,15,19,25, 28-nonamethyl-33-[(E,2R)-2-methylhex-4-enoyl]-6,9,18, 24-tetraki...

CAS No 121584-18-7 , (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-1,4,7,10,12,15,19,25,
28-nonamethyl-33-[(E,2R)-2-methylhex-4-enoyl]-6,9,18,
24-tetrakis(2-methylpropyl)-3,21,30-tri(propan-2-yl)-1,4,7,10,13,16,19,
22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,
32-undecone

  • Name: (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-1,4,7,10,12,15,19,25,
    28-nonamethyl-33-[(E,2R)-2-methylhex-4-enoyl]-6,9,18,
    24-tetrakis(2-methylpropyl)-3,21,30-tri(propan-2-yl)-1,4,7,10,13,16,19,
    22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,
    32-undecone
  • Synonyms: 3'-Keto-bmt(1)-val(2)-cyclosporin A; PSC-833; PSC833;Amdray; Sdz-psc-833; Sdz psc 833; Psc 833; Amdray (TN);(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-1,4,7,10,12,15,19,25,
    28-nonamethyl-33-[(E,2R)-2-methylhex-4-enoyl]-6,9,18,
    24-tetrakis(2-methylpropyl)-3,21,30-tri(propan-2-yl)-1,4,7,10,13,16,19,
    22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,
    32-undecone; 121584-18-7;
  • CAS Registry Number:
  • Flash Point: 734°C
  • Boiling Point: 1290.1°Cat760mmHg
  • Density: 1.015g/cm3
  • Refractive index: 1.466
  • Flash Point: 734°C
  • Molecular Weight: 1214.62194
  • InchiKey: YJDYDFNKCBANTM-QCWCSKBGSA-N
  • InChI: InChI=1S/C63H111N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)
    61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70
    (21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)
    59(82)72(23)47(32-37(8)9)60(83)73(24)51(40(14)15)63(86)74(52)25/h26-27,
    34-47,49-52H,28-33H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)(H,67,
    80)/b27-26+/t41-,42+,43-,44+,45+,46+,47+,49+,50+,51+,52+/m1/s1
  • Molecular Formula: C63H111N11O12
  • Molecular Structure:CAS No:121584-18-7 (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-1,4,7,10,12,15,19,25,<br />28-nonamethyl-33-[(E,2R)-2-methylhex-4-enoyl]-6,9,18,<br />24-tetrakis(2-methylpropyl)-3,21,30-tri(propan-2-yl)-1,4,7,10,13,16,19,<br />22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,<br />32-undecone

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121584-18-7 VALSPODAR

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121584-18-7 Cyclosporin A,6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-

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References of (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-1,4,7,10,12,15,19,25,
28-nonamethyl-33-[(E,2R)-2-methylhex-4-enoyl]-6,9,18,
24-tetrakis(2-methylpropyl)-3,21,30-tri(propan-2-yl)-1,4,7,10,13,16,19,
22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,
32-undecone
Title: Valspodar
CAS Registry Number: 121584-18-7
CAS Name: 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic acid]cyclosporin D
Synonyms: [3￠-desoxy-3￠-oxo-MeBmt]1-[Val]2-cyclosporin; [3￠-keto-Bmt1]-[Val2]-cyclosporin
Manufacturers' Codes: PSC-833; SDZ-PSC-833
Trademarks: Amdray (Novartis)
Molecular Formula: C63H111N11O12
Molecular Weight: 1214.62
Percent Composition: C 62.30%, H 9.21%, N 12.68%, O 15.81%
Literature References: Nonimmunosuppressive cyclosporin analog that reverses multidrug resistance (MDR) by inhibiting cellular drug efflux mediated by P-glycoprotein, q.v. Prepn: P. Bollinger et al., EP 296122; eidem, US 5525590 (1988, 1996 both to Sandoz). Pharmacology: D. Boesch et al., Exp. Cell Res. 196, 26 (1991). Clinical pharmacokinetics: R. M. Lush et al., J. Clin. Pharmacol. 37, 123 (1997). HPLC determn in blood: M. G. Scott et al., Clin. Chem. 43, 505 (1997). Clinical evaluation in multiple myeloma: P. Sonneveld et al., Leukemia 10, 1741 (1996); in acute myelogenous leukemia: R. Advani et al., Blood 93, 787 (1999). Review of pharmacology and clinical efficacy: F. Loor, Expert Opin. Invest. Drugs 8, 807-835 (1999).
Properties: Insol in water. Sol in ethanol, DMSO. [a]D20 -255.1° (c = 0.5 in CHCl3).
Optical Rotation: [a]D20 -255.1° (c = 0.5 in CHCl3)
Therap-Cat: Antineoplastic adjunct (chemosensitizer).
Keywords: Antineoplastic Adjunct; Chemosensitizer.