Title: Citiolone
CAS Registry Number: 1195-16-0
CAS Name: 2-Acetamido-4-mercaptobutyric acid g-thiolactone
Synonyms: N-(tetrahydro-2-oxo-3-thienyl)acetamide;
N-acetylhomocysteinethiolactone; a-acetamido-g-thiobutyrolactone; AHCTL
Manufacturers' Codes: BO-714
Trademarks: Citiolase (HMR)
Molecular Formula: C6H9NO2S
Molecular Weight: 159.21
Percent Composition: C 45.26%, H 5.70%, N 8.80%, O 20.10%, S 20.14%
Literature References: Prepn: Wagner
et al., DE 1134683 (1962 to Degussa, vorm Roessler),
C.A. 58, 4648c (1963); Nakanishi
et al., JP 62 16712 (1962 to Yoshitomi),
C.A. 59, 11660h (1963); Takayananagi
et al., JP 64 3420,
C.A. 61, 3193h (1964); Ogino, Yasui,
JP 65 1376,
C.A. 62, 14822c (1965) (1964, 1965 both to Sumitomo). Chemistry: Benesch, Benesch,
J. Am. Chem. Soc. 78, 1597 (1956); Laliberté
et al., J. Chem. Soc. 1963, 2756. Pharmacology: E. -J. Kirnberger
et al., Arzneim.-Forsch. 8, 72 (1958); Varga
et al., ibid. 13, 1867 (1963).
Properties: Needles from toluene, mp 111.5-112.5°. uv max: 238 nm (e 4400). LD50 i.v. in mice: 1200 mg/kg (Kirnberger).
Melting point: mp 111.5-112.5°
Absorption maximum: uv max: 238 nm (e 4400)
Toxicity data: LD50 i.v. in mice: 1200 mg/kg (Kirnberger)
Use: Photographic antifogging agent: Dersch,
US 3068100 (1962); Weber,
DE 1164828 (1964 to Adox Fotowerke Schleussner GmbH),
C.A. 60, 14050f (1964); protector against radiation: Langendorff, Koch,
Strahlentherapie 106, 451 (1958); Braun
et al., ibid. 108, 262 (1959),
C.A. 52, 18841h (1958);
53, 17325e (1959).
Therap-Cat: In treatment of hepatic disorders.
Keywords: Hepatoprotectant.
