Home > Name List By other > (8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15, 16-octahydrocyclopenta[a]phenanthrene-3,17-dione

CAS No 107868-30-4 , (8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,
16-octahydrocyclopenta[a]phenanthrene-3,17-dione

  • Name: (8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,
    16-octahydrocyclopenta[a]phenanthrene-3,17-dione
  • Synonyms: 6-Methyleneandrosta-1,4-diene-3,17-dione; 107868-30-4; Exemestano [INN-Spanish]; Exemestanum [INN-Latin];(8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,
    16-octahydrocyclopenta[a]phenanthrene-3,17-dione; Exemestance;Aromasin;
  • CAS Registry Number:
  • Melting Point: 155.13 ºC
  • Flash Point: 169 ºC
  • Boiling Point: 453.7 ºC at 760 mmHg
  • Density: 1.13 g/cm3
  • Refractive index: 1.572
  • Safety Statements: Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.
  • Hazard Symbols: A reproductive hazard.
  • Flash Point: 169 ºC
  • Molecular Weight: 296.40336
  • InchiKey: BFYIZQONLCFLEV-DAELLWKTSA-N
  • InChI: InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,
    3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,
    2-3H3/t14-,15-,16-,19+,20-/m0/s1
  • Molecular Formula: C20H24O2
  • Molecular Structure:CAS No:107868-30-4 (8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,<br />16-octahydrocyclopenta[a]phenanthrene-3,17-dione

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107868-30-4 Exemestane

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107868-30-4 Exemestane

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107868-30-4 Exemestane

  • Exemestane Product Name: Exemestane Chemical Name: 6-Methylenandrosta-1,4-diene-3,17-dione; Molecular Formula: C20H24O2 Molecular weight: 296.40 CAS NO.: 107868-30-4 Assay: 99% Appearance: white to almost white powder Standard: Enterprise Standard
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107868-30-4 Exemestane

  • Exemestane Product Name: Exemestane Chemical Name: 6-Methylenandrosta-1,4-diene-3,17-dione; Molecular Formula: C20H24O2 Molecular weight: 296.40 CAS NO.: 107868-30-4 Assay: 99% Appearance: white to almost white powder Standard: Enterprise Standard
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107868-30-4 EXEMESTANE

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  • Exemestane, 99,9%
  • United States AvaChem Scientific LLC [Manufacturer]
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References of (8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,
16-octahydrocyclopenta[a]phenanthrene-3,17-dione
Title: Exemestane
CAS Registry Number: 107868-30-4
CAS Name: 6-Methyleneandrosta-1,4-diene-3,17-dione
Manufacturers' Codes: FCE-24304
Trademarks: Aromasin (Pharmacia & Upjohn)
Molecular Formula: C20H24O2
Molecular Weight: 296.40
Percent Composition: C 81.04%, H 8.16%, O 10.80%
Literature References: Irreversible aromatase inhibitor. Prepn: E. Di Salle et al., DE 3622841; F. Buzzetti et al., US 4808616 (1987, 1989 both to Farmitalia Carlo Erba). Pharmacology: D. Giudici et al., J. Steroid Biochem. 30, 391 (1988). HPLC determn in plasma: M. Breda et al., J. Chromatogr. 620, 225 (1993). Clinical pharmacology: T. R. J. Evans et al., Cancer Res. 52, 5933 (1992). Review of clinical experience in primary and secondary therapy for breast cancer: J. M. Dixon, Expert Rev. Anticancer Ther. 2, 267-275 (2002). Clinical trial in sequential therapy following tamoxifen in breast cancer: R. C. Coombes et al., N. Engl. J. Med. 350, 1081 (2004).
Properties: White to slightly yellow crystalline powder. mp 188-191°. uv max: 247 nm (e 13750). Freely sol in DMF; sol in methanol. Practically insol in water.
Melting point: White to slightly yellow crystalline powder. mp 188-191°
Absorption maximum: uv max: 247 nm (e 13750)
Therap-Cat: Antineoplastic (hormonal).
Keywords: Antineoplastic (Hormonal); Aromatase Inhibitors; Aromatase Inhibitors.