Vismodegib

VismodegibVismodegib(GDC-0449) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM; also inhibits P-gp with IC50 of 3.0 μM.

IC50 value: 3 nM (hedgehog); 3.0 uM (P-gp) [1]

Target: hedgehog

in vitro: GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling.

Target:Dopamine Receptor

Product Links:http://www.medchemexpress.cn/vismodegib.html

Permanent link:http://www.medchemexpress.com/vismodegib.html

Permanent link: http://www.vvchem.com/sell/cas:879085-55-9,3322499.html