MLN120BMLN120B is a potent and effective IKKbeta inhibitor.
IC50 Value: MLN120B (20 umol/L) induced up to 35% and 75% inhibition, assessed by MTT assay and [3H]thymidine uptakein multiple myeloma cell lines, respectively.
Target: IKKbeta
NF-κB pathway blockers, such as MLN120B, are currently being explored for treatment of inflammatory diseases such as COPD and asthma[3].
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Description: MLN4924 MLN4924 is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50 = 4.7 nM). IC50 value: 4.7 nM Target: NAE At much higher concentrations, MLN 4924 inhibits the related enzymes ubiquitin-activating enzyme (UAE) an...
Description: MLN 2480 MLN 2480(BIIB-024) is an oral, selective pan-Raf kinase inhibitor in chinical trials. IC50 value: Target: pan-Raf in vitro: MLN-2480 is active against wild-type B-raf and B-raf Val600Glu in vitro. Target: Sirtuin Product Links: http://www.me...