L-Thyroxine

L-Thyroxine

Synonyms: levothyroxine; l-t4; t4(hormone); o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosin; o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine; tetraiodothyronine
CAS: 51-48-9
EINECS: 200-101-1
Assay: 99% min. USP30
Loss on dry:≤1%
Melting point:233℃-235℃
Heavy metal:≤10ppm
MF: C15H11I4NO4
MW: 776.87
Character: White Crystalline Solid.
Usage: One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the p.
Packing: 1 kg /foil bag or tin.
Payment: Bank Transfer, Western Union, Money Gram
Express: EMS, DHL, FedEx, etc(door-to-door)
Delivery: Safe & timely, around 1-3 days after payment

Description:
Levothyroxine (INN, USAN) or L-thyroxine is a synthetic thyroid hormone that is chemically identical to thyroxine (T4), which is naturally secreted by the follicular cells of the thyroid gland. It is used to treat thyroid hormone deficiency, and occasionally to prevent the recurrence of thyroid cancer. Like its naturally secreted counterpart, levothyroxine is a chiral compound in the L-form. The related drug dextrothyroxine (D-thyroxine) was used in the past as a treatment for hypercholesterolemia (elevated cholesterol levels) but was withdrawn due to cardiac side effects.
Levothyroxine is typically used to treat hypothyroidism, and is the treatment of choice for patients with hypothyroidism, who often require lifelong thyroid hormone therapy. It may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing. Levothyroxine is also used as interventional therapy in patients with nodular thyroid disease or thyroid cancer to suppress thyroid-stimulating hormone (TSH) secretion. In 1992, President George H. W. Bush told television host Larry King that he had been prescribed levothyroxine as part of a treatment regimen for Graves' disease.

Application:
Levothyroxine for systemic administration is available as an oral tablet, an intramuscular injection, and as a solution for intravenous infusion. [10] Furthermore, levothyroxine is available as both brand-name and generic products. [6] While the United States Food and Drug Administration (FDA) approved the use of generic levothyroxine for brand-name levothyroxine in 2004, the decision was met with disagreement by several medical associations.
Side effects: This medication should not be used for weight loss. Normal doses of this medication will not work for weight loss, and large doses of this medication may cause serious, possibly fatal side effects, especially when taken with diet pills.

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