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Isotretinoin

  • CAS No.: 4759-48-2
  • Purity: 99%
  • Min quantity: 1000 Kilograms
  • Price: USD 1~2/Kilograms
  • Place of Orign: wuhan,Hubei,China
Ms.Merry Zhou

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Item specifics

  • Product Name.:Isotretinoin
  • CAS No: 4759-48-2
  • Weight: 300.44
  • Formula: C20H28O2
  • Melting Point: 174-177 ºC
  • Boiling Point: 462.8 °C at 760 mmHg
  • Density: 1.011 g/cm3

Details

Isotretinoin
Synonyms: 13-cis-ra;13-cis-retinoicaci;13-ra;accutane;Isoretinoin;isotrex;neovitaminaacid;ro-4-3780
CAS: 4759-48-2
MF: C20H28O2
MW: 300.44
EINECS: 225-296-0
Product Categories: Antibiotics;Organic acids;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids
Chemical Properties: Yellow-Orange Crystalline Powder
Usage: Used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin.
Air & Water Reactions: Insoluble in water.
Packing:100g/foil bag

Application:

Isotretinoin is used to treat severe cystic acne (also known as nodular acne) that has not responded to other treatment (e.g., benzoyl peroxide or clindamycin applied to the skin or tetracycline or minocycline taken by mouth).

Isotretinoin is primarily used as a treatment for severe acne. The most common adverse effects are a transient worsening of acne (lasting 2-3 weeks), dry lips (cheilitis), dry and fragile skin, and an increased susceptibility to sunburn.

As the retinoid, there are strong and fast proliferation inhibition and differentiation of skin gland cell function, effective on severe nodular cystic acne. The gastrointestinal absorption is better, while the local medication invalid. Other drugs used to treat invalid serious acne, cystic acne, acne conglobata, rosacea, ichthyosis, keratosis follicularis and pityriasis rubra pilaris and other skin diseases also have a certain effect.

For severe acne. Anti skin dyskeratosis medicine. For the treatment of severe acne and other disorders

ITEMS STANDARDS RESULTS
Appearance A white to off white powder White powder
Identification A. Meets the requirement Complies
B. IR: similar to Reference Substance Complies
Loss on drying ≤0.5% 0.21%
Specific Rotation +10.0°~+13.0° +10.8°
Related Substances Any single impurity ≤0.1% Total impurity ≤0.8% 0.05% 0.10%
Purity By HPLC R-isomer ≤0.15% 0.10
Residue on ignition ≤0.1% 0.05%
Residual solvents Isopropyl alcohol ≤5000ppm Ethyl Acetate ≤5000ppm 150ppm 250ppm
Heavy metals ≤10ppm Complies
Chlorides ≤0.05% Complies
Assay 98%~102.0% 99.8%
Conclusion Analyse according to Factory Standard , Conform
Isotretinoin

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