AP20187AP20187 is a synthetic, cell-permeable ligand that can be used to induce homodimerization of fusion proteins containing the DmrB domain.
Target: small dimerizer drug
Systemic AP20187 administration results in time-dependent LFv2IRE tyrosine phosphorylation and activation of the insulin signaling pathway in both liver and muscle of AAV-treated NOD mice.
MedChemexpress(MCE)provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use. MCE has an enthusiastic, energetic and friendly Technical and Customer Support team with years of experience in the Life Science industry. MCE lay great attention on the purity, stability and activity of the compounds, esp. You can rely on us to be a com...
View more >>
Description: AP1903 AP1903 is a homodimer binding to FKBP; elicites potent and dosedependent apoptotic death of engineered cell line HT1080 in culture with an EC50 of 0.1 nM IC50 value: 0.1 nM (EC50, HT1080) [1] Target: FKBP regulator AP1903 is a ideal reagents f...