AP1903AP1903 is a homodimer binding to FKBP; elicites potent and dosedependent apoptotic death of engineered cell line HT1080 in culture with an EC50 of 0.1 nM
IC50 value: 0.1 nM (EC50, HT1080) [1]
Target: FKBP regulator
AP1903 is a ideal reagents for controlling the activities of cells that have been modified by gene therapy procedures, without interference from endogenous FKBP.
Constitutive hGH secretion provides a convenient and accurate
way to monitor the number of viable cells in vivo because hGH
has a serum half-life of only '3 min in mice (22, 23).
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Description: AP20187 AP20187 is a synthetic, cell-permeable ligand that can be used to induce homodimerization of fusion proteins containing the DmrB domain. Target: small dimerizer drug Systemic AP20187 administration results in time-dependent LFv2IRE tyrosine p...